pimozide


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pimozide

 [pi´mah-zīd]
an antipsychotic agent and antidyskinetic agent used in the treatment of gilles de la tourette's syndrome; administered orally.

pimozide

/pi·mo·zide/ an antipsychotic and antidyskinetic agent used in the treatment of Gilles de la Tourette's syndrome.

pimozide

(pĭm′ə-zīd′)
n.
An antipsychotic drug, C28H29F2N3O, used in the management of Tourette syndrome.

pimozide

[pim′əzīd]
an antipsychotic agent from the diphenylbutylpiperidine class.
indications It is prescribed for the suppression of motor and phonic tics associated with Gilles de la Tourette's syndrome.
contraindications It may cause electrocardiography changes, including a prolonged QT interval, and should not be given to patients with a congenital prolonged QT interval or a history of cardiac arrhythmias. It also may lower the seizure threshold of patients who are also taking an anticonvulsant drug. It should not be taken concurrently with drugs that are inhibitors of CYP3a4 (e.g., ketoconazole, erythromycin).
adverse effects Among the more serious adverse effects are extrapyramidal effects, persistent tardive dyskinesia, sedation, drowsiness, constipation, dry mouth, visual disturbances, and electrocardiograph changes.

pimozide

A long-acting phenothiazide antipsychotic drug of the diphenylbutylpiperidine group that is also used in the treatment of the GILLES DE LA TOURETTE'S SYNDROME. A brand name is Orap.

pimozide,

n brand name: Orap;
drug class: antipsychotic, antidyskinetic;
action: blocks dopamine effects on central nervous system;
uses: motor and phonic tics in Giles de la Tourette's syndrome.

pimozide

an antipsychotic agent in humans; used for its long-acting central antiemetic effect in dogs.
References in periodicals archive ?
The authors concluded saying that administration of Pimozide or related drugs would be an effective treatment in human severe asthmatic patients.
Pimozide in dermatologic practice: a comprehensive review.
Previous research using the matching law procedure to study the effects of drugs on reinforcement efficacy and motor performance has shown that dopamine antagonists such as chlorpromazine and pimozide decrease the efficacy of water (Heyman et al.
Norvir should not be taken with the following medicines: astemizole, terfenadine, amiodarone, bepridil, encainide, flecainide, propafenone, quinidine, dihydroergotamine, ergotamine, ergonovine, methylergonovine, clorazepate, diazepam, estazolam, flurazepam, triazolam or oral (taken by mouth) midazolam, clozapine, pimozide, pethidine, piroxicam, propoxyphene, cisapride rifabutin, voriconazole, simvastatin, lovastatin, alfuzosin, fusidic acid, sildenafil used to treat a lung disease called pulmonary arterial hypertension, and products containing St John's wort (Hypericum perforatum).
In the new study, pimozide was the most lethal of six anti-psychotic drugs tested by a team from UNSW and the University of Queensland.
Improvement of trigeminal neurotrophic ulceration with pimozide in a cognitively impaired elderly woman: a case report.
From analyses, she found that the most promising was the anti-psychotic called pimozide, which killed lung, breast and brain cancer cells in-vitro.
Special Considerations: Emend is a weak to moderate CYP3A4 inhibitor, so it should not be used with pimozide, terfenadine, astemizole, or cisapride.
It should not be taken with pimozide, terfenadine, astemizole, and cisapride.
The current therapeutics market is served by approved drugs such as haloperidol and pimozide and off-label drugs such as Abilify (aripiprazole), risperidone, clonidine and tetrabenazine.
The traditional neuroleptics pimozide (Orap), haloperidol (Haldol), and fluphenazine (Prolixin) are the only drugs with regulatory approval for Tourette syndrome.