pimobendan


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pimobendan

phosphodiesterase inhibitor used for its positive inotropic effect and vasodilation in management of heart failure in dogs.
References in periodicals archive ?
The EPIC Study (evaluating pimobendan in dogs with cardiomegaly) involved treating 180 dogs who had audible murmurs with a drug, while others were put on a placebo.
Pimobendan improves the ability of the heart to pump blood forward and dilates blood vessels.
Calcium sensitivity and the effect of the calcium sensitizing drug pimobendan in the alcoholic isolated rat atrium.
Various empirical treatments have been reported for birds suffering from congestive heart failure, including furosemide, spironolactone, enalapril, pimobendan, (47) and supportive care.
The drugs include diuretics to remove excess fluid that builds up in the lungs when a dog is in congestive heart failure; ACE (angiotensin converting enzymes) to slow heart enlargement, relieve strain on the heart and reduce blood pressure; and pimobendan, which works to dilate blood vessels and improve the force of contraction of heart muscle.
The drug pimobendan delays the onset of heart failure linked to mitral valve disease (MVD), the most common heart complaint suffered by dogs.
So the following study was undertaken to evaluate the efficacy of Pimobendan in the management of CHF in dogs.
Rector TS, Cohn JN (1992) Assessment of patient outcome with the Minnesota Living with Heart Failure questionnaire: reliability and validity during a randomized, double-blind, placebo-controlled trial of pimobendan.
Pimobendan e inodilatadores, nuevas estrategias en el manejo de la ICC.
Este nuevo grupo de medicamentos inotropicos se ha denominado "sensibilizadores del calcio" y se han descrito tres tipos de acuerdo con el mecanismo de accion, entre ellos los que aumentan la afinidad del calcio por la troponina como el pimobendan, los que prolongan los cambios estructurales del complejo troponina inducidos por el calcio como el levosimendan y los que tienen efecto directo sobre los puentes de actina- miosina (3).
Medicamentos: la incorporacion temprana de medicamentos como espironolactona o pimobendan han mostrado un mayor tiempo de sobrevida (6,12).