pilocarpine


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pilocarpine

 [pi″lo-kahr´pin]
a cholinergic alkaloid from leaves of Pilocarpus jaborandi and P. microphyllus; used topically in the eye as the base or the hydrochloride or nitrate salt as an antiglaucoma agent and miotic; the hydrochloride salt is also used orally to treat mouth dryness resulting from radiotherapy or associated with Sjögren's syndrome. The nitrate salt has also been administered by iontophoresis to produce sweating in a test for cystic fibrosis.

pi·lo·car·pine

(pī'lō-kar'pēn),
An alkaloid obtained from the leaves of Pilocarpus microphyllus or P. jaborandi (family Rutaceae), shrubs of the West Indies and tropical America; a parasympathomimetic agent used experimentally to induce seizures externally as a miotic and in the treatment of glaucoma; used as the hydrochloride and the nitrate salts.
[G. pilos, a felt hat, + karpos, fruit]

pilocarpine

/pi·lo·car·pine/ (pi″lo-kahr´pēn) a cholinergic alkaloid, used as the base or the hydrochloride or nitrate salt as an antiglaucoma agent and miotic and as the hydrochloride salt in the treatment of xerostomia associated with radiotherapy or Sjögren's syndrome.

pilocarpine

(pī′lō-kär′pēn′)
n.
A colorless or yellow poisonous compound, C11H16N2O2, obtained from the leaves of the jaborandi and used to induce sweating, promote salivation, and treat glaucoma.

pilocarpine

Therapeutics An alkaloid with mild β-adrenergic activity which, topically, ↓ intraocular pressure in glaucoma; it stimulates glands, resulting in diaphoresis, salivation, lacrimation it may be used to treat post-radiation or opioid-induced xerostomia, gastric and pancreatic secretion

pi·lo·car·pine

(pī'lō-kahr'pēn)
An alkaloid obtained from the leaves of Pilocarpus microphyllus or P. jaborandi, shrubs of the West Indies and tropical Americas; a parasympathomimetic agent used experimentally to induce seizures externally as a miotic and in the treatment of glaucoma.
[G. pilos, a felt hat, + karpos, fruit]

pilocarpine

A drug used in the form of eye-drops to treat GLAUCOMA. Pilocarpine causes extreme constriction of the pupils so that traction is exerted on the root of the iris so as to open up the drainage channels for aqueous humour. The drug is on the WHO official list. Brand names are Minims pilocarpine, Pilogel, Salagen, Sno Pilo, and, in the form of a sustained-release insert placed behind an eyelid and left for a week at a time, Ocusert Pilo.

pilocarpine 

An alkaloid obtained from the leaves of Pilocarpus microphyllus and other species of Pilocarpus. It is a parasympathomimetic (direct-acting cholinergic) drug, which mimics the effect of acetylcholine causing miosis and accommodation. It counteracts sympathomimetic mydriatics. It is used in the treatment of glaucoma. Pilocarpine hydrochloride is most commonly applied to the eye as a 1% solution. Carbachol and bethanechol chloride are other parasympathomimetic drugs with similar effects to pilocarpine. See parasympathomimetic drug; physostigmine.

pi·lo·car·pine

(pī'lō-kahr'pēn)
An alkaloid used experimentally to induce seizures externally as a miotic and to treat glaucoma.
[G. pilos, a felt hat, + karpos, fruit]

pilocarpine (pi″lokahr´pēn),

n an alkaloid that causes parasympathetic effects (e.g., secretion of salivary, bronchial, and gastrointestinal glands). It stimulates the sweat glands and also causes vasodilation and cardiac inhibition.

pilocarpine

a cholinergic alkaloid from leaves of Pilocarpus jaborandi and P. microphyllus; used as an ophthalmic miotic in the form of its hydrochloride and nitrate salts.
References in periodicals archive ?
Four doses of the whole extract (30, 60, 90, and 150 mg/kg) were tested in the pilocarpine model.
TM)] is a novel, patent-protected therapeutic that combines the muscarinic antagonist tolterodine with a modified-release formulation of the muscarinic agonist (salivary stimulant) pilocarpine.
5mg pilocarpine, administered BID) was studied in a 12-week open-label extension period, in a subset of patients in this Phase 2 trial.
Pilocarpine HCI tablets are indicated for 1) the treatment of symptoms of dry mouth from salivary gland hypofunction caused by radiotherapy for cancer of the head and neck; and 2) the treatment of symptoms of dry mouth in patients with Sjogren's syndrome.
We are quite pleased with the results of the study in that by taking pilocarpine three or four times a day in pill form salivary flow was better than taking placebo.
Marillion Acquires Exclusive Worldwide Rights to Pilocarpine Buccal Insert for Xerostomia and Sjogren's Syndrome from Cytokine PharmaSciences
Professor Williams and colleagues used the pilocarpine animal model of seizures to evaluate the neuroprotective effects of lamotrigine.
Nasdaq: MOGN) reported that presentations at the VII International Symposium on Sjogren's Syndrome in Venice, Italy noted a variety of benefits to Sjogren's syndrome patients who take pilocarpine HCl, the active ingredient in MGI PHARMA's Salagen(R) Tablets.
Food and Drug Administration (FDA) of its Abbreviated New Drug Application (ANDA) for Pilocarpine HCl tablets.
presented data from an abstract entitled "Sustained Increases in Salivary Flow and Safety Findings Following Extended Use of Pilocarpine Tablets for the Treatment of Dry Mouth Symptoms in Patients with Sjogren's Syndrome.
Tenders are invited for Supply of Pilocarpine eye drops ip 2% w v 2014