physostigmine


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physostigmine

 [fi″zo-stig´mēn]
a cholinergic alkaloid having anticholinesterase activity, obtained from the dried ripe seed (Calabar bean) of Physostigma venenosum; used topically to produce miosis and to decrease intraocular pressure in glaucoma. It may also be applied parenterally to reverse the central nervous system effects produced by overdosage of anticholinergic drugs.

phy·so·stig·mine

(fī'sō-stig'mēn),
An alkaloid of physostigma; it is a reversible inhibitor of the cholinesterases and prevents destruction of acetylcholine; used as a cholinergic agent, and experimentally to enhance the action of acetylcholine at any of its sites of liberation.
Synonym(s): eserine

physostigmine

/phy·so·stig·mine/ (-stig´mēn) a cholinergic alkaloid usually obtained from dried ripe seed of Physostigma venenosum (Calabar bean), used as a topical miotic and to reverse the central nervous system effects of an overdosage of anticholinergic drugs; used in the form of the salicylate and sulfate salts.

physostigmine

(fī′sō-stĭg′mēn′) also

physostigmin

(-mĭn)
n.
A crystalline alkaloid, C15H21N3O2, extracted from the Calabar bean, used in the form of its sulfate as a miotic and in the form of its salicylate as a cholinergic agent. Also called eserine.

physostigmine

A reversible antiacetylcholinesterase, used in Pts with Sx of an anticholinergic crisis Neurology Memory drug Physostigmine may improve working memory by ↑ efficiency and ↓ effort. See Working memory.

phy·so·stig·mine

(fī'sō-stig'mēn)
A nonpolar carbamate antidote to anticholinergic compounds.

physostigmine

A CHOLINESTERASE inhibitor drug used to constrict the pupil of the eye and lower the pressure within the eye in GLAUCOMA. It is also used to treat poisoning with ANTICHOLINERGIC drugs. It is derived form the Calabar bean Physostigma venenosum . Also known as eserine.

physostigmine 

A reversible anticholinesterase drug used as a parasympathomimetic which, when used in the eye constricts the pupil. It may be used in solution of 0.25-1% or ointment 0.25-0.50% in the treatment of glaucoma, but because of its side-effects its usage is rare nowadays. It is sometimes combined with pilocarpine. Syn. eserine. See miotics; neostigmine; parasympathomimetic drug.

phy·so·stig·mine

(fī'sō-stig'mēn)
Alkaloid used as a cholinergic agent, and experimentally to enhance action of acetylcholine at any of its sites of liberation.

physostigmine (fī´sōstig´mēn),

n a cholinergic actylcholinesterase inhibitor prescribed in the treatment of some forms of glaucoma and to reverse effects of neuromuscular blocking agents.

physostigmine

an alkaloid usually obtained from the dried ripe seed of Physostigma venenosum; used as a topical miotic in the form of the base and of the salicylate and sulfate salts.

physostigmine challenge test
a test for the diagnosis of cataplexy; after increasing doses of physostigmine, affected dogs show a dose-related severity of reactions when offered food.
References in periodicals archive ?
Acetylthiocholine iodide, acetylcholinesterase from electric eel (AChE), 5,5'-dithiobis[2-nitrobenzoic acid] (DTNB), butyryl-cholinesterase from equine serum (BChE), S-butyrylthiocholine chloride, physostigmine and galanthamine were purchased from Sigma Chemicals (St.
Salen, P, Shih R, Sierzenski P, Reed J Effect of Physostigmine and Gastric Lavage in a Datura Stramonium-induced anticholinergic poisoning epidemic.
Both scopolamine and physostigmine induced blood flow changes in limbic brain regions, but the flow patterns were different in cocaine addicts and healthy subjects.
Physostigmine was shown in a placebo-controlled study, to improve verbal long-term storage and retrieval in 4 percent of 36 subjects with TBI with severe memory impairment [78].
Physostigmine effects on serotonin uptake in human blood platelets.
Oleic acid (3%) was successful in enhancing the flux of the tetrapeptide melanotropin-hisetal across hairless mouse skin and human skin, but enhancement across human skin was much less (25,26) and oleic acid (50:50) produced greater transdermal delivery of physostigmine than propionic acid alone (27).
It is administered locally in the mouth where physostigmine diffuses through the mucosa reaching the minor glands.
Julian's patents was for his process for synthesizing physostigmine for the treatment of glaucoma.
And while physostigmine is the standard antidote for overdoses involving pure anticholinergic agents, it is contraindicated in TCA overdoses because of several case reports of asystolic cardiac arrest.
Oral physostigmine has also been reported to increase blood pressure, presumably through central sympathetic activation.
Myristicaceae Physostigmine Positive control 2) Houghton and Howes, 2005 Acetylcholinesterase (AChE) are inhibitors Acetylcholinesterase (AChE) is an enzyme that degrades acetylcholine.