Sunlight-activated insecticides: Historical background and mechanisms of phototoxic
Alpha-terthienyl, a non-photodynamic phototoxic
4) Primary photosensitization is a cutaneous disorder that results from ingestion of phototoxic
burning may occur, although extreme blistering and oedema is more a feature of Gunther's disease--the rarer autosomal recessive form (3).
The carotenoids also appear to protect humans against phototoxic
GOTHENBURG, SWEDEN -- A resorbable subcutaneous implant of afamelanotide significantly reduced painful phototoxic
attacks in patients with erythropoietic protoporphyria in a year-long multinational clinical trial.
The present investigation was a preliminary screening for phototoxic
activity in natural products with antibacterial activities from medicinal plants used in Brazil.
Results released today from a Phase III trial of the drug SCENESSE (R), conducted by Melbourne-based Clinuvel Pharmaceuticals Limited (ASX:CUV) (PINK:CLVLY), have shown that the drug has the ability to reduce and prevent painful phototoxic
reactions experienced by patients with erythropoietic protoporphyria (EPP).
There results exhibited that HepG2 was resistant to the phototoxic
effect of these two photosensitizers with concentrations up to 4uM and light dose of 40 J/cm2 (Chi-Fung, et al.
The clinical name for the condition is phytophotodermatitis (PPD), sometimes called phototoxic
dermatitis [see inset photo on previous page].
When the light is combined with the drug, phototoxic
reactions induce the destruction of bacterial cells.
Other plants, such as giant hogweed Heracleum mantegazzianum and garden rue Ruta graveolens, cause a phototoxic