Photosensitive skin reactions can be the consequence of topical or systemic use of the drug, where phototoxic
or photoallergic reactions can occur as a side effect (8-11).
Psoriasis was commonly seen in sixteen cases, airborne allergic contact dermatitis was noticed in nine cases, two cases each was seen in scabies and lichen planus, one case each was noticed in ichthyosis, phototoxic
dermatitis, pityriasis rubra pilaris, pemphigus foliaceus, dermatophytosis respectively, this correlates with study of Pal and Haroon et.
dermatitis (DFS), also known as hepatogenic or secondary photosensitization, is defined as skin sensitivity to sunlight due to the presence of photodynamic agents (1) in severe cases of photosensitive dermatitis.
Additional drugs that can produce phototoxic
reactions include amiodarone, psoralens and phenothiazines, anticancer drugs, retinoids, zidovudine, and quinine.
However, other factors such as sex and environmental influences such as smoking cigarettes, heart and vascular disorders, hypertension, dyslipidemia/hypercholesterolemia, diabetes, obesity, improper diet, sedentary lifestyle, and phototoxic
exposure are also important [179-181].
Although, berberine is phototoxic
 but Berberis aristata extract found safe with LD50greater than 5000 mg/kg body weight in mice  which is in accordance to this research in which it showed higher LC50.
However, this has a phototoxic
effect and causes the cells to deteriorate.
The uses of these chemical compounds and synthetic coating materials have not practical applications due to the high cost, lack of availability and phototoxic
effects (Purkayastha, 2009).
The latter compounds exhibited phototoxic
activity in a Lemna minor bioassay (7).
maculopathy associated with arc welding: clinical findings and associated functional vision impairment.
These essential oils are phototoxic
and can cause pigmentation changes and skin burns up to 12 hours after application when exposed to the sun.
Recently, bio-pesticides with plant origin are given for use against several insect species, especially disease transmitting vectors, based on the fact that compounds of plant origin are safer to use, without phototoxic
properties and leave no scum in the environment (15).