photosensitizer


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Related to photosensitizer: Photoexcitation

photosensitizer

Oncology A substance that sensitizes an organism, cell, or tissue to light; an agent used in photodynamic therapy which, when absorbed by CA cells and exposed to light, is activated, killing cancer cells. See Photodynamic therapy.

photosensitizer

(fō″tō-sĕn′sĭ-tī″zĕr)
A substance that, in combination with light, will cause a sensitivity reaction in the substance or organism.
References in periodicals archive ?
The photosensitizer, rose bengal or meso-tetra (N-methyl-4-pyridyl) porphyrintetratosylate, generated singlet oxygen, which acts as a strong oxidizing agent of specific amino acids like tryptophan found in the active site of AchE (Michaeli & Feitelson 1994).
The pattern of tumor markers like MPO, [beta]-D-glucuronidase and rhodanese in our study clearly show that photodynamic therapy using embelin as a photosensitizer certainly possess clinical applications.
From the point of view of its potential application in the PDT of cancer pyropheophorbide a methyl ester (PPME) is a therapeutic second generation photosensitizer (Al-Omari and Ali, 2009).
PDT clinical trials using a photosensitizer, as well as a variety of second-generation photosensitizer, has shown promise in treating malignancies of the esophagus, bronchus, brain, peritoneal cavity, skin, bladder, head and neck, as well as in treating nononcologic disorders such as age-related macular degeneration.
Effect of photosensitizer diethylamine on the photodegradation of polychlorinated biphenyls.
Only tissues exposed to bath photosensitizer and light are damaged.
Vascular accumulation of novel photosensitizer MV6401 cases selective thrombosis in tumor vessels following photodynamic therapy.
By comparing the data collected, similar photobleaching rates were identified and the dielectric properties of the subcellular location of the photosensitizer were elucidated.
Indeed, typically there is a modest enhanced accumulation of the photosensitizer in tumor tissues and an additional selectivity is mainly provided by the confined illumination of the target area.
The visible light driven response via anion doping will eliminate the need for a ruthenium dye as photosensitizer, offering promise of a low cost and greatly simplified hybrid design.
In a preliminary study, Alexiades-Armenakas examined whether a combination of photodynamic therapy (PDT) with a photosensitizer known as topical 5-aminolevulinic acid (ALA) and activated by long-pulse, pulsed dye laser could safely and effectively clear mild to severe cases of acne.
The in vivo antitumour activity of the natural photosensitizer hypericin was evaluated.