It has been shown to inhibit photocarcinogenesis
in animal studies.
12) A meta-analysis from the Journal of Cosmetic Dermatology reported that topical vitamin E is effective in reducing erythema, sunburn cells, and photocarcinogenesis
, and that high doses of oral vitamin E reduce chronic UV-B-induced skin damage.
Chemoprevention of photocarcinogenesis
by selected dietary botanicals.
Extrinsic skin aging, also named as skin photoaging, is mainly caused by sun exposure, which could eventually result in photocarcinogenesis
including malignant melanoma.
Inflammation, gene mutation and photoimmunosuppression in response to UVR-induced oxidative damage contributes to photocarcinogenesis
15 It is reported that FA could increase expression of Bax with concomitant decreased Bcl-2 in the photocarcinogenesis
progress of male Swiss albino mice skin.
Ultraviolet (LA/) light, consisting of UVA (320-400 nm), UVB (280-320 nm) and UVC (100-280 nm), is one of the most common factors leading to DNA damage and inflammatory responses, consequently resulting in various cutaneous lesions such as photoaging and photocarcinogenesis
(Scharffetter-Kochanek et al.
Niacinamide has been shown to prevent photoimmunosuppression in humans and photocarcinogenesis
CDI Ib+ cells are the major source of oxidative stress in UV radiation-irradiated skin: possible role in photoaging and photocarcinogenesis
It reduces photocarcinogenesis
in mice, and human non-melanoma skin cancers (NMSC) in Phase 2 clinical trials.
4, 9) The UVB action spectrum that is responsible for the sunburn response and photocarcinogenesis
is involved in vitamin D biosynthesis.
Sun exposure is the major cause of photocarcinogenesis
(7, 8, 13), photosensitivity (12, 13) and photoaging (9, 12).