phosphorylation


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phosphorylation

 [fos″for-ĭ-la´shun]
the process of introducing a phosphate group into an organic molecule.
oxidative phosphorylation the final common pathway of aerobic energy metabolism in which high-energy phosphate bonds are formed by phosphorylation of ADP to ATP coupled with the transfer of electrons along a chain of carrier proteins with molecular oxygen as the final acceptor. It occurs in mitochondria.

phos·phor·y·la·tion

(fos'fōr-i-lā'shŭn),
Addition of phosphate to an organic compound, such as glucose to produce glucose monophosphate, through the action of a phosphotransferase (phosphorylase) or kinase.

phosphorylation

/phos·phor·y·la·tion/ (fos-for″ĭ-la´shun) the metabolic process of introducing a phosphate group into an organic molecule.
oxidative phosphorylation  the formation of high-energy phosphate bonds by phosphorylation of ADP to ATP coupled to the transfer of electrons from reduced coenzymes to molecular oxygen via the electron transport chain; it occurs in the mitochondria.
substrate-level phosphorylation  the formation of high-energy phosphate bonds by phosphorylation of ADP to ATP (or GDP to GTP) coupled to cleavage of a high-energy metabolic intermediate.

phosphorylation

[fosfôr′ilā′shən]
the process of attaching a phosphate group to a protein, sugar, or other compound.

phos·phor·y·la·tion

(fos'fŏr-i-lā'shŭn)
Addition of phosphate to an organic compound, such as glucose to produce glucose monophosphate, through the action of a phosphotransferase (phosphorylase) or kinase.

phosphorylation

The addition of a phosphate group to an organic molecule.

phosphorylation

the process in which one of more phosphate groups is added to a molecule. Such reactions occur regularly in biological systems. For example, in AEROBIC RESPIRATION glucose is phosphorylated in GLYCOLYSIS; ADP is phosphorylated to ATP at the substrate level and via the ELECTRON TRANSPORT SYSTEM; in plants ATP is produced by PHOTOPHOSPHORYLATION.

phos·phor·y·la·tion

(fos'fŏr-i-lā'shŭn)
Addition of phosphate to an organic compound, such as glucose to produce glucose monophosphate, through the action of a phosphotransferase (phosphorylase) or kinase.

phosphorylation (fos´fərəlā´shən),

n the addition of phosphate to an organic compound.

phosphorylation

the process of introducing a phosphate group into an organic molecule.

oxidative phosphorylation
the final common oxidative pathway in which high-energy phosphate bonds are formed by phosphorylation of ADP to ATP by harnessing by F0,F1-ATPase of the proton motive force generated from pumping of protons from the matrix of mitochondria across the inner mitochondrial membrane to the intermembrance space and is coupled with the transfer of electrons along a chain of carrier proteins with molecular oxygen as the final acceptor.
References in periodicals archive ?
Immunoblotting analysis revealed that the tyrosine phosphorylation level of all Kv channels included in this study increased more significantly after hypoxia in IUGR-hypoxia rats than in control-hypoxia rats.
In the insulin signal transduction pathway, insulin binds with a receptor that exhibits autophosphorylation and tyrosine kinase activity; this receptor causes IRS phosphorylation and transmits the signal further.
Mock-preloaded cells showed expected increases in the phosphorylation of all three ATM targets by Cr(VI) but, in striking contrast, no responses were detected in +Asc cells (Figure 2B).
MAB 391, a neutralizing anti-IGF-1 receptor antibody, significantly attenuated Ang II- and IGF-1-induced phosphorylation of ERK1/2 and AKT, while it had no effect on the Ang II-and insulin-induced responses (Figure 3).
We discovered that formononetin could enhance the survival of H9c2 cells and inhibit the mPTP opening through the potential mechanisms involving the inhibition of ROS production and Akt- and PKC-mediated phosphorylation of GSK-3[beta] at Ser9.
For Part 1, the p70S6K phosphorylation in PBMCs of liver transplant patients receiving different immunosuppressive drug regimens by phospho-flow cytometry and Western blotting.
The compounds with at least one cluster showing the best pose and docked energy in the structural pocket of Serine 276 phosphorylation was then tested for anti-angiogenic activity through a wet-lab study involving a Chorio-allantoic membrane (CAM) assay for angiogenesis.
preferring serine-glutamine (SQ) or threonine-glutamine (TQ) sequences as the phosphorylation targets.
The phosphorylation of S6 is thought to be required for the translation of a subset of mRNAs that contain a 5'-oligopyrimidine tract at their transcriptional start sites (5'-terminal oligopyrimidine, 5'-TOP) (Iwenofu et al.
The research centred on eukaryotic initiation factor 2 alpha (eIF2alpha) and two enzymes that modify it with a phosphate group; this type of modification is termed phosphorylation.
Western blotting of phosphorylated signalling molecules revealed that UVB irradiation (80 mJ/cm(2)) significantly stimulated the phosphorylation of p38, ERK and JNK, which was not suppressed by treatment with AX after irradiation.
Different post-translational modifications (PTMs) such as phosphorylation and glycosylation control the function of SIRT1.

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