He and his team, including co-first authors Clmentine Gibard, Subhendu Bhowmik, and Megha Karki, all postdoctoral research associates at TSRI, showed first that DAP could phosphorylate
each of the four nucleoside building blocks of RNA in water or a paste-like state under a wide range of temperatures and other conditions.
Interferon binds with the receptor; Janus-Kinase phosphorylates
tyrosine residues which then auto phosphorylates
1997) Stress-activated protein kinase/c-jun N-terminal kinase phosphorylates
TRADD then recruits TRAF2, RIP and other molecules, leading to the formation of the TNF-R1 signalling complex, downstream of NIK activation, NIK then phosphorylates
Some kinases such as CKI are intimately bound to the NF preparation extracted from axoplasm, suggesting it may phosphorylate
ser/thr sites in the glutamine-acid-rich region of the NF tail domains and play an important role in regulating axon transport (Floyd et al.
All IFN[alpha]s and IFN[beta] bind to the same receptor and as a result, the cytoplasmic kinases JAK1 and TYK2 become activated and phosphorylate
the STAT1 and STAT2 molecules.
Phosphorylation of kinase-1 happens faster than phosphatase can reverse it, and kinase-1 starts to phosphorylate
and activate other kinase-1 molecules.
This in turn directly phosphorylates
MEKK1 leading to activation of the N-terminal c-Jun kinase (JNK-1) pathway, a known pro-apoptotic signaling pathway.
Several studies have shown that DNA-PK phosphorylates
XRCC4 in vitro, decreasing its interaction with DNA, although the significance of these phenomena is presently unclear.
It's known that mental retardation can result from mutation of ATR, a DNA damage-sensing protein that phosphorylates
The phosphoamino acid analysis specifically showed that PKC[alpha] phosphorylates
on serine(s) and ERK1 phosphorylates
on threonine(s) of N-DAT.
Specifically, P-TEFb phosphorylates
DSIF so that DSIF can switch on and off the process of gene expression.