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phospholipidosis

   Also found in: Wikipedia 0.01 sec.
phospholipidosis
a generalized phospholipid disturbance with major deposits, derived from alveolar surfactant, in the pulmonary alveoli.
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3) The initial underlying pathologic process in the lung from amiodarone toxicity is postulated to be a drug-induced phospholipidosis, (9) and the mechanism by which phospholipids accumulate in the cell is believed to be by inhibition of intracellular phospholipase when the drug and its metabolites are trapped in alveolar macrophages and type II pneumocyte lysosomes.
Endogenous lipoid pneumonia by Kanne, Jeffrey P.; Thoongsuwan, Nisa; Stern, Eric J. / Applied Radiology
Toxicogenomics approach to drug-induced phospholipidosis (Hiroshi Sawada).
Research and Markets: 'Toxicogenomics: A Powerful Tool for Toxicity ... by Business Wire
The study examined the feasibility of obtaining higher throughput results using the quantitative Nuclease Protection Assay (qNPA(TM)) method versus the standard PCR-based testing approach in testing 12 specific gene markers of drug-induced phospholipidosis on HepG2 cells.
New Peer-Reviewed Data Published in Toxicology in Vitro Shows ... by Business Wire
 
 
 
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