phospholipase A2

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phos·pho·lip·ase A2

an enzyme that catalyzes the hydrolysis of a lecithin to a lysolecithin by removing the 2-acyl group; also acts on other phospholipids by removing a fatty acid from the 2-position; this enzyme has an important role in prostaglandin and leukotriene biosynthesis.
Synonym(s): lecithinase A, phosphatidase, phosphatidolipase


A gene on chromosome 8q23.1 that encodes an adapter protein which regulates a broad spectrum of general and specialised signalling pathways by binding to a large number of partners, usually by recognising a phosphoserine or phosphothreonine motif.

phospholipase A2

enzyme catalyzing the hydrolysis of the fatty acyl group esterified in the 2-position of a phospholipid. Key enzyme in the release of arachidonic acid from this position for subsequent conversion to the eicosanoid group of humoral agents.
References in periodicals archive ?
Clinical utility of lipoprotein-associated phospholipase A2 for cardiovascular disease prediction in a multiethnic cohort of women.
BanI polymorphism of cytosolic phospholipase A2 gene is associated with age at onset in male patients with schizophrenia and schizoaffective disorder.
Lipoprotein-associated and secretory phospholipase A2 in cardiovascular disease: the epidemiological evidence.
Lipoprotein-associated phospholipase A2 as an independent predictor of coronary heart disease.
Blood pressure medications known as angiotensin-converting enzyme (ACE) inhibitors also lower peak phospholipase A2, and some scientists have suggested that the therapeutic efficacy of cardiovascular drugs may depend, to some degree, on their ability to lower markers of vascular inflammation such as Lp-PLA2.
Attacks of FIVIF are associated with various markers of inflammation, which are reflected: a) clinically by fever and pain in the affected sites b) histologically by an invasion of polymorphonuclear leukocytes to the serosal membranes c) serologically by activation of the cytokine cascade with elevated levels of IL-6 and soluble receptors of TNF and particularly by the increased production of the acute phase plasma proteins, fibrinogen, CRP, serum Amyloid A and phospholipase A2 (2).
Overexpression of group II phospholipase A2 in human breast cancer tissues is closely associated with their malignant potency.
Weichel O, Hilgert M, Chatterjee SS, Lehr M, Klein J (1999) Bilobalide, a constituent of Ginkgo biloba, inhibits NMDA-induced phospholipase A2 activation and phospholipid breakdown in rat hippocampus.
Christie Ballantyne, Director of the Center for Cardiovascular Disease Prevention at Baylor College of Medicine and the Methodist DeBakey Heart Center in Houston, reported that both lipoprotein-associated phospholipase A2 (Lp-PLA2) and high-sensitivity C-Reactive Protein (hs-CRP) are independently associated with the incidence of coronary artery disease.
FAROOQUI is a leader in the fields of signal transduction, brain phospholipase A2, bioactive ether lipid metabolism, and polyunsaturated fatty acid metabolism, among others.
A prospective evaluation of lipoprotein-associated phospholipase A2 levels and the risk of future cardiovascular events in women.

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