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Enzymes cleaving bonds in phosphodiesters, such as those in cAMP or between nucleotides in nucleic acids, liberating smaller polynucleotide or oligonucleotide units or mononucleotides but not orthophosphate.


Enzymes cleaving phosphodiester bonds, such as those in cyclic adenosine monophosphate or between nucleotides in nucleic acids, liberating smaller poly- or oligonucleotide units or mononucleotides but not inorganic phosphate.
References in periodicals archive ?
Phosphodiesterase isozymes: Molecular targets for novel antiasthma agents.
Phosphodiesterase inhibitors in the treatment of inflammatory diseases.
Phosphodiesterase 4 and its inhibitors in inflammatory diseases.
The specific type IV phosphodiesterase inhibitor rolipram suppresses tumor necrosis factor-alpha production by human mononuclear cells.
Characterization of cAMP-dependent inhibition of LPS-induced TNF alpha production by rolipram, a specific phosphodiesterase IV (PDE IV) inhibitor.
Regulation of distinct cyclic AMP-specific phosphodiesterase (phosphodiesterase type 4) isozymes in human monocytic cells.
Evidence that cyclic AMP phosphodiesterase inhibitors suppress TNF alpha generation from human monocytes by interacting with a 'low-affinity' phosphodiesterase 4 conformer.
SB 207499 (Ariflo), a potent and selective second-generation phosphodiesterase 4 inhibitor: In vitro anti-inflammatory actions.
Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-alpha responses.
Specific role of phosphodiesterase 4B in lipopolysaccharide-induced signaling in mouse macrophages.
Impaired growth and fertility of cAMP-specific phosphodiesterase PDE4D-deficient mice.

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