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phosphodiesterase inhibitor

   Also found in: Dictionary/thesaurus, Legal, Encyclopedia, Wikipedia 0.01 sec.
phos·pho·di·es·ter·ase inhibitor (fsf-d-st-rs, -rz)
n.
Any of a class of drugs that suppress the enzyme phosphodiesterase, increasing the production of cyclic GMP, which facilitates vasodilation, causing erection in males.

inhibitor
1. any substance that interferes with a chemical reaction, growth or other biological activity.
2. a chemical substance that inhibits or checks the action of a tissue organizer or the growth of microorganisms.
3. an effector that reduces the catalytic activity of an enzyme.

coagulation i's
clotting factors.
fibrinolytic i's
clotting factors.
phosphodiesterase inhibitor
inhibits phosphodiesterase, which in turn inactivates cyclic adenosine monophosphate. The effect of the inhibitor is to increase the heart muscle content of cAMP.
reversible i's
pharmaceutical inhibitors which have only a temporary effect, e.g. the cholinesterase inhibitors neostigmine, physostigmine.


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ABSTRACT A simple, rapid, and sensitive high-performance liquid chromatographic method was developed and validated for determination of tadalafil, a selective and reversible phosphodiesterase inhibitor, in human serum.
None of the samples contained vardenafil (Levitra), a third phosphodiesterase inhibitor.
Theophylline is a nonselective phosphodiesterase inhibitor.
 
 
 
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