phosphodiesterase inhibitor

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Related to phosphodiesterase inhibitor: sildenafil, Viagra, Milrinone

phosphodiesterase inhibitor

Abbreviation: PDE inhibitor
Any agent that blocks phosphodiesterase, inhibiting the production of second messengers within cells, such as cyclic adenosine monophosphate or cyclic glucose monophosphate. Drugs that inhibit PDE include sildenafil, an agent used to treat erectile dysfunction, and other agents used as positive inotropes and vasodilators in heart failure.
See also: inhibitor

phosphodiesterase inhibitor

positive inotrope (e.g. enoximone [Perfan]); see inotrope


1. any substance that interferes with a chemical reaction, growth or other biological activity.
2. a chemical substance that inhibits or checks the action of a tissue organizer or the growth of microorganisms.
3. an effector that reduces the catalytic activity of an enzyme.

coagulation i's
clotting factors.
fibrinolytic i's
clotting factors.
phosphodiesterase inhibitor
inhibits phosphodiesterase, which in turn inactivates cyclic adenosine monophosphate. The effect of the inhibitor is to increase the heart muscle content of cAMP.
reversible i's
pharmaceutical inhibitors which have only a temporary effect, e.g. the cholinesterase inhibitors neostigmine, physostigmine.
References in periodicals archive ?
A : These drugs all belong to a class of medication known as phosphodiesterase inhibitors (PDEIs) and work by the same mechanism.
Sildenafil, marketed as Viagra, does appear in the guidelines, which acknowledge that some patients "wish to try nonspecific therapy" But the section on sildenafil and two other investigational oral phosphodiesterase inhibitors does not appear until page 12.
Phosphodiesterase inhibitors as a new generation of antiprotozoan drugs: exploiting the benefit of enzymes that are highly conserved between host and parasite Thomas Seebeck, Geert Jan Sterk, Hengming Ke
of Cedars-Sinai Medical Center, a $750,000 grant to fund his study of phosphodiesterase inhibitors (sildenafil and taladafil) as a possible therapy for Duchenne.
There also has been interest in phosphodiesterase inhibitors, which have not only bronchodilator properties but also immune-suppressive properties.
Pipeline candidates fall under major therapeutic classes such as Anti-CD20 Mab, Bcl-2 Inhibitors, CDK Inhibitors, Multi TKIs, Immunomodulators, Phosphodiesterase Inhibitors, HDAC Inhibitors and Proteasome Inhibitors.
Medical Treatment of PAH: Phosphodiesterase Inhibitors
Other targets of depression research include phosphodiesterase inhibitors and other areas associated with neuroprotective and neurotrophic effects in the CNS.

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