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A dihydrochalcone occurring in many parts of the apple tree; used experimentally to produce glycosuria in animals.
Synonym(s): phlorizin


, phlorizin, phloridzin (flōr′ĭ-zĭn, flŏ-rīz′ĭn) (flōr′ĭd-zĭn, flŏ-rid′zĭn) [Gr. phloios, phloos, bark + rhizo- + -in]
A glycoside present in the bark of some fruit trees. It is a powerful inhibitor of sugar transport in some animals.

phloridzin, phlorizin

a dihydrochalcone extracted from the root bark of the apple tree. Thought at one time to be present in cherry, plum and pear. Blocks the renal tubular reabsorption of glucose hence promoting the development of glycosuria.
References in periodicals archive ?
Huang, Preparative separation and identification of flavonoid phloridzin from the crude extract of sweet tea (Lithocarpus polystachyus Rehd.
Huge Reductions in Insulin Levels with Popular Dietary Supplements Resveratrol 47% reduction (29) Omega-3 34% reduction (30) Green tea 22% reduction (62) Ginseng 13% reduction (63) Additional Ways to Help Control Insulin Levels Nutrient Impact L-arabinose (40,42) Lowers insulin levels; reduces insulin resistance Chromium (43,47) Enhances insulin sensitivity; lowers insulin levels Coffee (48-51) Improves insulin resistance; IGF-1 levels are lower in women coffee drinkers Phaseolus vulgaris (white Lowers insulin levels kidney bean) and other legume extracts (52-55) Phloridzin (56-58) Normalizes glucose tolerance and insulin sensitivity Sorghum (59-61) Improves insulin sensitivity; lowers insulin levels
Anti-aging effects of phloridzin, an apple polyphenol, on yeast via the SOD and Sir2 genes," Bioscience, Biotechnology and Biochemistry, vol.
PG is a phloridzin derivative and its main use is in rooting [24, 25, 26] but sometime it could be used as a component that reduce vitrification and increase proliferation [27, 28].
Appjfnol[R] (including apple phloretin, phloridzin, polyphenol, chlorogenic acid etc)
Phloridzin (phloretin-2'-0-glucoside), a non-selective SGLTs inhibitor has been shown to protect against the deleterious effects of diabetic cardiomyopathy in db/db mice (Cai et al.
Phloridzin is a natural polyphenol heavily concentrated in the skin of an apple.
This idea is supported by studies reporting that phloridzin, the 2'-0-glucoside of phloretin, has anti-diabetic properties (DimitraKoudis et al.
One polyphenol, phloridzin, which is heavily concentrated in the skin of the apple, also potently suppresses several processes leading to glycation, another major contributor to aging.
Phytonutriance Appl'In patented apple extract is standardized to 80% polyphenols and 5% phloridzin for weight management applications.
Polyphenol glycosides are absorbed mainly through the gut barrier after deglycosylation by the action of lactase phloridzin hydrolase in the brush border of the small-intestine epithelial cells, cytosolic [beta]-glucosidase within the epithelial cells, or colonic microbiota in the large intestine (Crozier et al.