phenylpyruvic acid


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phenylpyruvic acid

 [fen″il-pi-roo´vik]
an intermediate product of the metabolism of phenylalanine in the body.

phe·nyl·py·ru·vic ac·id

(fen'il-pī-rū'vik as'id),
The transaminated product of the action of phenylalanine aminotransferase; elevated in the urine in individuals with phenylketonuria.

phenylpyruvic acid

/phen·yl·py·ru·vic ac·id/ (-pi-roo´vik) an intermediary product produced when the normal pathway of phenylalanine catabolism is blocked and excreted in the urine in phenylketonuria.

phenylpyruvic acid

[fen′ilpīro̅o̅′vik]
a product of the metabolism of phenylalanine. The presence of phenylpyruvic acid in the urine is indicative of phenylketonuria.

phe·nyl·py·ru·vic ac·id

(fen'il-pī-rū'vik as'id)
The transaminated product of the action of phenylalanine aminotransferase; elevated in the urine in people with phenylketonuria.

phenylpyruvic acid

an intermediate product of the metabolism of phenylalanine in the body.
References in periodicals archive ?
ii) Phenylpyruvic acid is termed as keto acid because of its molecular structure; hence, the disease is known as phenylketonuria or PKU.
Phenylpyruvic acid (PPY) (Sigma USA) pyruvic acid (PYR) 2-oxobutyric acid (KB) 3- methyl-2-oxobutyric acid (MKBA) 2-oxoglutaric acid (KG) 3-methyl 2-oxovaleric acid (K3MVA)4-methyl-2-oxovaleric acid (K4MVA) monosodium salt (Fluka Switzerland) were used.
There are several consequences associated with the enzyme deficiency: phenylalanine and phenylpyruvic acid levels are increased in blood and tissues; urinary phenylpruvic acid, phenylacetic acid, and phenylalanine are increased; and, there is a deficiency of tyrosine that leads to a decrease in the production of melanin and other important neurochemicals.
Although these children do not necessarily have PKU, they do suffer from the consequences of increased levels of phenylalanine and phenylpyruvic acid in the mother's blood (Teplin, 2004).
Because it may take from 2 to 6 weeks for urinary excretion of phenylpyruvic acid, screening for this metabolite is not a part of the initial screening.
Nine a-keto acids: glyoxylic acid (GA), pyruvic acid (PYR), 2- oxobutyric acid (KB), 3-methyl-2-oxobutyric acid (MKBA), 3-methyl-2-oxovaleric acid (K3MVA), 2-oxoglutaric acid (KG), 4-methyl-2-oxovaleric acid (K4MVA), 2-oxohexanoic acid (KHA) and phenylpyruvic acid (PPY) were derivatized with (NPD) at pH 3 and separated on a Zorbax 300 SB-C18 HPLC column (4.
The concentration of phenylpyruvic acid increases in the serum of patients with hereditary metabolic diseases [9].
Pyruvic acid overlaps with phthalic, N-acetylaspartic, and glycolic acids; pyroglutamic acid overlaps with 3-hydroxybutyric acid; phenylpyruvic acid overlaps with orotic and hydroxyisovaleric acids; and p-hydroxyphenyl pyruvic and phenyllactic acids overlap with xanthurenic and homogentisic acids.
1966) Reduction of phenylpyruvic acids to phenyllactic acids in mammalian tissues.