phenylephrine


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phenylephrine

 [fen″il-ef´rin]
an adrenergic with potent vasoconstrictor properties; used as the hydrochloride salt for various purposes: topically to decongest nasal and laryngeal mucous membranes or to produce mydriasis without cycloplegia; intravenously to maintain blood pressure during spinal and inhalation anesthesia, to treat vascular failure in drug-induced shock, shocklike states, and hypotension, to prolong spinal anesthesia, and to treat paroxysmal supraventricular tachycardia; and orally as a component of combination antihistaminic-decongestant preparations.

phenylephrine

/phen·yl·eph·rine/ (-ef´rin) an adrenergic used as the hydrochloride salt for its potent vasoconstrictor properties.

phenylephrine

(fĕn′əl-ĕf′rēn, fē′nəl-)
n.
An adrenergic drug, C9H13NO2, that is a powerful vasoconstrictor and is used to relieve nasal congestion, dilate the pupils, and maintain blood pressure during anesthesia.

phenylephrine

A SYMPATHOMIMETIC drug used as eye drops to dilate the pupils for ophthalmic examination of the interior of the eyes. A brand name is Minims phenylephrine.

phenylephrine

an α-adrenergic stimulant used as the hydrochloride salt as a nasal decongestant and in ophthalmology to produce mydriasis.
References in periodicals archive ?
In a second vote, the panel's experts voted 9 to 3 to urge that further study be undertaken to explore the efficacy of phenylephrine at higher doses, including 25 milligrams.
Reduction of phenylephrine drop size in infants achieves equal dilation with decreased systemic absorption.
The results of the present study indicated that the prophylactic infusion of low doses of ephedrine (10 mg) and phenylephrine (125 [micro]g) before spinal anesthesia for cesarean section, caused a significant decrease in the frequency and severity of maternal hypotension, need for vasoactive drugs, nausea, vomiting, need for antiemetic drug, and an increase in the Apgar score of neonates.
6] M phenylephrine (see first set of experiments), aortic rings with intact endothelium were preincubated for 30 min with one (or two) of various compounds in order to explore the mechanisms involved in the vasorelaxant effect produced by clobenzorex.
Many guidelines offer the choice of ephedrine or phenylephrine as the vasopressor, including the National Institute for Health and Care Excellence (NICE) [23] and SA guidelines.
When hypotension developed, 2 ml boluses of vasopressor were administered every minute, corresponding to 2 mg of etilefrine or 50 [micro]g of phenylephrine, until the SBP and/or MBP values were above the limits established to join the trial.
The incidence of hypotension was 32% in phenylephrine 4mg group, 42% in ephedrine 45mg group, 70% in the phenylephrine 2mg group and 86% in the control group.
Groups were comprised of the tropicamide group (n = 29; 24%), the phenylephrine group (n = 29; 24%), the cyclopentolate group (n = 32; 27%), and the control group (n = 30; 25%).
The company expects to begin shipment of its product, ibuprofen and phenylephrine hydrochloride tablets (200 mg/10 mg), before the upcoming cough, cold and flu season.
Advocates of phenylephrine claim better fetal acid-base status, and similar efficacy in blood pressure control, but its use is associated with bradycardia [2] and serial dilution for i.