phenylbutazone


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phenylbutazone

 [fen″il-bu´tah-zōn]
a nonsteroidal antiinflammatory drug administered orally in the short-term treatment of severe rheumatoid disorders unresponsive to less toxic agents. It is given for periods of less than one week because it can cause aplastic anemia and agranulocytosis.

phenylbutazone

/phen·yl·bu·ta·zone/ (-bu´tah-zōn) a nonsteroidal antiinflammatory drug used in the short-term treatment of severe rheumatoid disorders unresponsive to less toxic agents.

phenylbutazone

Therapeutics An NSAID tightly bound to plasma proteins. See NSAIDs.

phenylbutazone

A non-steroidal anti-inflammatory drug (NSAID) once widely used but now available for use in hospitals only because of its tendency to cause HEART FAILURE from fluid retention and severe blood disorders. It is used, under specialist supervision, in cases of ANKYLOSING SPONDYLITIS.

phenylbutazone

a powerful anti-inflammatory drug first used in the 1940s in the treatment of arthritis. Limited by its potentially serious side effects (including fatalities), it is now rarely used in humans (ankylosing spondylitis is an exception) but interestingly is used in equestrian sports to treat soft tissue injuries in horses.

phenylbutazone

pyrazole painkiller, used to treat ankylosing spondylitis

phenylbutazone

a nonsteroidal anti-inflammatory drug resembling cortisone in its action; used in the treatment of painful conditions of joints and skeletal muscles. It has powerful analgesic and antipyretic effects, but causes bone marrow suppression with high doses or prolonged administration.
References in periodicals archive ?
As in the case we report, 7/8 horses received dimethyl sulfoxide, flunixin meglumine, and phenylbutazone intravenously, and 2 dexamethasone intravenously for 1-3 days.
Comparison of adverse effects of phenylbutazone, Flunixinmeglumin, and Ketoprofen in horses.
The 37 head of cattle that were treated with Phenylbutazone are to remain isolated, whilst the untreated 224 animals have been cleared for slaughtering for human consumption in local and international markets.
According to the book Goat Medicine, you may try aspirin (100 mg/kg every 12 hours) or phenylbutazone (10 mg/kg once a day).
The following drugs may increase the effectiveness of insulin, resulting in hypoglycemia: ACE inhibitors, alcohol, anabolic steroids, beta blockers, calcium, chloroquine, clofibrate, clonidine, disopyramide, fluoxetine, guanethidine, lithium, mebendazole, monoamine oxidase inhibitors, octreotide, pentamidine, phenylbutazone, propoxyphene, pyridoxine, salicylates, sulfinpyrazone, sulfonamides, and tetracyclines.
All but 2 of these 13 criteria (use of bepridil or phenylbutazone as first-line therapy) reference drug-drug interactions, and all can produce severe consequences.
The inhibitors used were aspirin (0-acetylsalicylic acid), phenylbutazone (4-butyl-3, 5-dioxo-1, 2-diphenyl pyrazolidine), indomethacin (1-[p-chloro-benzoyl]-2-methyl-5-methoxy-indoleacetic acid) and niflumic acid (2-[3[prime]-trifluoromethylanilino]-nicotinic acid).
For instance, chloramphenicol, a powerful antibiotic, and phenylbutazone, an anti-inflammatory drug, have been linked to aplastic anemia, an irreversible and usually fatal disease that strikes the bone marrow.
Priority product focus is on injectable pharmaceuticals such as penicillin, phenylbutazone, oxytetracycline, and lidocaine used to keep livestock and companion animals healthy and to prevent and treat disease.
The topical nature of this patch's delivery system means gastric ulceration associated with some systemic drug treatments, such as the NSAID Phenylbutazone, will be eliminated," he said.
The tests found no traces of the horse pain-killing drug phenylbutazone, which has been found during inspections elsewhere in Europe.
Last week Asda reported a test on its corned beef had tested positive for horse drug phenylbutazone, or bute.