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phentolamine

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phentolamine
[fentol′əmēn]
an alpha1-adrenergic receptor blocker.
indications It is prescribed in the control of symptoms of pheochromocytoma before and during surgery and for dermal necrosis and sloughing after extravasation of parenteral drugs with alpha-adrenergic effects (e.g., norepinephrine, epinephrine, dopamine).
contraindications History of myocardial infarction, angina, coronary artery disease, cerebrovascular disease, renal impairment, or known hypersensitivity to this drug prohibits its use.
adverse effects Among the more serious adverse effects are tachycardia, cardiac arrhythmias, anginal pain, and hypotension.

phentolamine
a potent α-adrenergic blocking agent; it blocks the hypertensive action of epinephrine and norepinephrine and most responses of smooth muscles that involve α-adrenergic cell receptors. Its hydrochloride and mesylate salts are used in the diagnosis of hypertension due to pheochromocytoma.


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