phenocopy


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Related to phenocopy: genocopy, Genetic heterogeneity

phenocopy

 [fe´no-kop″e]
1. an environmentally induced phenotype mimicking one usually produced by a specific genotype.
2. an individual exhibiting such a phenotype; the simulated trait in a phenocopy.

phe·no·cop·y

(fē'nō-kop'ē),
An environmentally induced mimic of a disease that is characteristically produced by a specific gene.
[G. phainō, to display, + copy]

phenocopy

/phe·no·copy/ (fe´no-kop″e) an environmentally induced phenotype mimicking one usually produced by a specific genotype.

phenocopy

(fē′nə-kŏp′ē)
n. pl. phenocop·ies
1. An environmentally induced, nonhereditary trait in an organism that closely resembles a genetically determined trait, especially a mutation.
2. An individual exhibiting such a trait.

phenocopy

[fē′nōkop′ē]
Etymology: Gk, phainein, to appear; L, copia, plenty
a phenotypic trait or condition that is induced by environmental factors but closely resembles a phenotype usually produced by a specific genotype. The trait is neither inherited nor transmitted to offspring. Such conditions as deafness, cretinism, mental retardation, and congenital cataracts are caused by mutant genes but can also result from a number of different agents, such as the rubella virus in the case of congenital cataracts. Because phenocopies may present problems in genetic screening and genetic counseling, all exogenous factors must be ruled out before any congenital trait or defect is labeled hereditary.

phe·no·cop·y

(fē'nō-kop-ē)
1. A set of clinical and laboratory characteristics that would ordinarily warrant the diagnosis of a specific genetic abnormality, but are of environmental rather than genetic etiology.
2. A condition of environmental etiology that mimics one usually of genetic etiology.
[G. phainō, to display, + copy]

phenocopy

A PHENOTYPE or disorder caused by non-genetic factors that mimics, and may be mistaken for, a genetic disorder.

phenocopy

a disorder or change that appears to be genetic in origin but actually is produced by environmental effects. An example is deafness in an infant that is caused by the GERMAN MEASLES virus rather than by an inherited condition. The distinction can be important in relation to the chances of an affected individual transmitting the condition to the next generation.

phenocopy

1. an environmentally induced phenotype mimicking one usually produced by a specific genotype.
2. an individual exhibiting such a phenotype; the simulated trait in a phenocopy.
3. experimentally produced phenocopies have been created in unfertilized rabbit eggs by the microinjection of the nuclei of embryonic rabbit cells.
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References in periodicals archive ?
8) Phenocopy is the presence of phenotypes in a sample that mimic those caused by genetic influences, but are instead the result of environmental influences.
The dsRNA control gene fragments have been used in RNAi studies and a twitcher phenocopy has been achieved, dsRNA for putative collagen IV cell surface receptors (ESTs) are in the process of being generated and will be utilized in RNAi studies.
Adaption and intelligence: Organic selection and phenocopy.
In particular, the phenocopy of a significant reduction in endoxifen plasma concentrations induced by SSRIs was observed in breast cancer patients homozygous for the wild-type CYP2D6 genotype, whereas the concentrations of other metabolites remained unaffected by the CYP2D6 genotype/phenotype.
RNAi uses short dRNA oligo-nucleotides to regions of expressed portions of genes to phenocopy a null mutation.
This is an example of a phenocopy, a person who develops a tumor in an organ at risk in hereditary cancer syndrome and does not have hereditary cancer syndrome.