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Related to phenazopyridine: phenazopyridine hydrochloride, Macrobid


a urinary tract analgesic, used as the hydrochloride salt; administered orally.


(fen-az-oh-peer-i-deen) ,


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Pyridium Plus

(trade name),

UTI Relief

(trade name)


Therapeutic: nonopioid analgesics
Pharmacologic: urinary tract analgesics
Pregnancy Category: B


Provides relief from the following urinary tract symptoms, which may occur in association with infection or following urologic procedures:
  • Pain,
  • Itching,
  • Burning,
  • Urgency,
  • Frequency.


Acts locally on the urinary tract mucosa to produce analgesic or local anesthetic effects.
Has no antimicrobial activity.

Therapeutic effects

Diminished urinary tract discomfort.


Absorption: Appears to be well absorbed following oral administration.
Distribution: Unknown. Small amounts cross the placenta.
Metabolism and Excretion: Rapidly excreted unchanged in the urine.
Half-life: Unknown.

Time/action profile (urinary analgesia)

POunknown5–6 hr6–8 hr


Contraindicated in: Hypersensitivity;Glomerulonephritis;Severe hepatitis, uremia, or renal failure;Renal insufficiency;Glucose-6–phosphate dehydrogenase (G6PD) deficiency.
Use Cautiously in: Hepatitis; Obstetric / Lactation: Safety not established.

Adverse Reactions/Side Effects

Central nervous system

  • headache
  • vertigo


  • hepatotoxicity
  • nausea


  • bright-orange urine (most frequent)
  • renal failure


  • rash


  • hemolytic anemia
  • methemoglobinemia


Drug-Drug interaction

None significant.


Oral (Adults) 200 mg 3 times daily for 2 days.
Oral (Children) 4 mg/kg 3 times daily for 2 days.

Availability (generic available)

Tablets: 95 mgOTC, 100 mg, 100 mgOTC, 200 mgOTC, 200 mg

Nursing implications

Nursing assessment

  • Assess patient for urgency, frequency, and pain on urination prior to and throughout therapy.
  • Lab Test Considerations: Renal function should be monitored periodically during course of therapy.
    • Interferes with urine tests based on color reactions (glucose, ketones, bilirubin, steroids, protein).

Potential Nursing Diagnoses

Acute pain (Indications)
Impaired urinary elimination (Indications)


  • Medication should be discontinued after pain or discomfort is relieved (usually 2 days for treatment of urinary tract infection). Concurrent antibiotic therapy should continue for full prescribed duration.
  • Oral: Administer medication with or following meals to decrease GI irritation. Do not crush, break, or chew tablet.

Patient/Family Teaching

  • Instruct patient to take medication exactly as directed. If a dose is missed, take as soon as remembered unless almost time for next dose.
  • Advise patient that while phenazopyridine administration is stopped once pain or discomfort is relieved, concurrent antibiotic therapy must be continued for full duration of therapy. Do not save unused portion of phenazopyridine without consulting health care professional.
  • Inform patient that drug causes reddish-orange discoloration of urine that may stain clothing or bedding. Sanitary napkin may be worn to avoid clothing stains. May also cause staining of soft contact lenses.
  • Instruct patient to notify health care professional if rash, skin discoloration, or unusual tiredness occurs.

Evaluation/Desired Outcomes

  • Decrease in pain and burning on urination.


/phen·a·zo·pyr·i·dine/ (fen″ah-zo-pir´ĭ-dēn) a urinary tract analgesic, used as the hydrochloride salt.


an azo dye, used as a urinary analgesic and antiseptic in humans. Causes hemolytic anemia and hepatic injury in cats.
References in periodicals archive ?
Interference by phenazopyridine with the leukocyte esterase dipstick.
Upon further questioning of her OTC medications, it was discovered that the chronic use of phenazopyridine accounted for all of the above-mentioned findings.
There have been a variety of case reports outlining the spectrum of diseases that can present as a result of phenazopyridine ingestion.
A prospective, randomized, double-blinded placebo-controlled comparison of extended release oxybutynin versus phenazopyridine for the management of postoperative ureteral stent discomfort.
Methemoglobinemia and Heinz body hemolytic anemia due to Phenazopyridine hydrochloride.
Hereditary HbM NADH-MetHb reductase deficiency Acquired Medications Amyl nitrite Benzocaine Dapsone Lidocaine Nitroglycerin Nitroprusside Phenacetin Phenazopyridine Prilocaine Quinones (chloroquinone, primaquine) Sulfonamides (sulfanilamide, sulfathiazide, sulfapyridine, sulfamethoxazole) Chemical agents Aniline dye derivatives (shoe dyes, inks) Butyl nitrite Chlorobenzene Nitrate-containing foods Isobutyl nitrite Naphthalene Nitrophenol Nitrous gases Silver nitrate Trinitrotoluene Well water nitrates Pediatric Decreased NADH-MetHb reductase activity (<4 months of age) Associated with low birth weight, prematurity, dehydration, acidosis, and diarrhea Table 3.
Phenazopyridine produces a bright orange- to red-colored urine specimen.
Able's product combines the two most commonly used drugs for treating UTIs -- sulfamethoxazole-trimethoprim and phenazopyridine, in an easy-to-use package that enhances compliance.
These side effects may be treated symptomatically with anticholinergics, acetaminophen or phenazopyridine hydrochloride.
5MG TAB Meclizine 25MG TAB Metoclopramide 10MG TAB Metoclopramide 5MG/5ML SYP Phenazopyridine 100MG TAB Phenazopyridine D 200MG TAB Promethazine 25MG TAB* Promethazine 6.
With the acquisition of Able, DynaGen also obtained the rights to ten ANDA products, including tablet or capsule formulations of bisacodyl, clorazepate, phenazopyridine, choline magnesium trisalicylate, mandelamine and salsalate.
Three reports have described sulfhemoglobinemia associated with phenazopyridine ingestion [12-14], and several others report dapsone ("DDS") as a cause [2,15-18].