pharmacophore

(redirected from pharmacophores)

pharmacophore

 [fahr´mah-ko-for″]
the group of atoms in the molecule of a drug responsible for the drug's action.

pharmacophore

(făr′mă-kō-for) [″ + phoros, bearing]
The three-dimensional shape of a molecule that makes it fit and activate cellular receptors.

pharmacophore

the group of atoms in the molecule of a drug responsible for the drug's action.
References in periodicals archive ?
Finally, the proposal will explore whether a further increase of anti-tumor efficiency can be obtained by combining Atg4B- and CA-inhibitor pharmacophores in a single compound.
Forge has been applying its metal-binding pharmacophores ("MBP") library and processes and has been able to identify potent drugable inhibitors of LpxC.
Thus, in order to overcome this state of crisis, a collective effort for the augmentation and synthesis of new drugs has spurred the chemists to search and formulate novel pharmacophores encompassing significant biological activities [5].
Forge Therapeutics has been implementing its proprietary metal-binding pharmacophores library and processes and has been able to identify potent drugable inhibitors of LpxC.
Part two discusses methods of scaffold hopping, covering 2D fingerprints, chemically advanced template search (CATS), reduced graphs, feature trees, feature point pharmacophores, 3D scaffold replacement, spherical harmonic molecular surfaces, XED force field and Spark, molecular interaction fingerprints, and SkelGen.
Besides the exploitation of new targets, there is another approach of merging two or more pharmacophores into a single molecule.
Characterization of two pharmacophores on the multidrug transporter P-glycoprotein.
The design and synthesis of hybrid molecules encompassing two pharmacophores in one molecular scaffold is a well-established approach to the synthesis of more potent drugs with dual activity.
While chiral carbinamines are common pharmacophores, a green, rapid.