phagosome


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Related to phagosome: Macrophages, autophagosome

phagosome

 [fag´o-sōm]
a membrane-bound vesicle in a phagocyte containing the phagocytized material.

phag·o·some

(fag'ō-sōm),
A vesicle that forms around a particle (bacterial or other) within the phagocyte that engulfed it, separates from the cell membrane, and then fuses with and receives the contents of cytoplasmic granules (lysosomes), thus forming a phagolysosome in which digestion of the engulfed particle occurs.
[phago- + G. sōma, body]

phagosome

/phago·some/ (fag´o-sōm) a membrane-bound vesicle in a phagocyte containing the phagocytized material.

phagosome

(făg′ə-sōm′)
n.
A membrane-bound vesicle found in a cell by an inward folding of the cell membrane to hold foreign matter taken into the cell by phagocytosis.

phagosome

[fag′əsōm]
a membrane-bound cytoplasmic vesicle within the phagocyte that engulfs it. The vesicle contains phagocytized materials and may fuse with a lysosome, forming a phagolysosome within which the lysosome digests the phagocytized material. Also called phagocytic vacuole.

phag·o·some

(fag'ō-sōm)
A vesicle that forms around a particle (bacterial or other) within the phagocyte that engulfed it, separates from the cell membrane, then fuses with and receives the contents of cytoplasmic granules (lysosomes), thus forming a phagolysosome in which digestion of the engulfed particle occurs.
[phago- + G. sōma, body]

phagosome

The vacuole, formed within a PHAGOCYTE, that surrounds material that has been taken up by cell membrane invagination. A phagosome may fuse with a lysosome to provide digestive enzyme.

phagosome

a membrane-bound vesicle in a phagocyte containing the phagocytized material. Called also a phagocytic vacuole.
References in periodicals archive ?
Previously, invading microorganisms were thought to be enveloped by the plasma membrane of the macrophage, an immune cell, and isolated into a newly-formed phagosome for degradation," said Desjardins, Caprion's director of proteomics and associate professor at the department of pathology and cellular biology of Universite de Montreal.
Such an antibody-based reaction in the phagosome would focus the toxic molecules on the cell's intended target, Lerner points out.
Lyn, PI3K and Akt were actively recruited to phagosome fractions in PA infected cells.
Although macrophages can kill phase II bacteria, phase I stages initially avoid death by inhibiting the final phagosome maturation step, but this function can be restored by [gamma]-interferon.
By revealing how precisely phagosomes, inside macrophages, produce the peptides that stimulate the proliferation of lymphocytes T, this research open up unforeseen pharmacological avenues for modulating this process, to create pioneering therapies for infectious diseases and cancer.
Identifying the ER as an integral part of the phagosome membrane could lead to new strategies and drugs for preventing and treating infection and new ways to promote phagosome maturation without the intrusion of infectious microbes.
However, in the spacious phagosomes, four organisms are clearly visible in each phagosome (Fig.
Metals might be retained in the phagosome after food particles and mucus are digested.
Another team from Hospital Santa Cruz de Liencres shares lessons learned from using phagosomes as immune tools in vaccination protocols.
Such concentrations may be achieved locally, for instance in phagosomes of infected macrophages (39).
These toxic granules enhance bactericidal activity, since bacteria in phagosomes are killed more effectively at a pH of 5.