phagolysosome


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phag·o·ly·so·some

(fag'ō-lī'sō-sōm),
A body formed by union of a phagosome or ingested particle with a lysosome having hydrolytic enzymes.

phagolysosome

a cytoplasmic body formed by the fusion of a phagosome, or ingested particle, with a lysosome containing hydrolytic enzymes. The enzymes digest most of the material within the phagosome.

phag·o·ly·so·some

(fag'ō-lī'sō-sōm)
A body formed by union of a phagosome or ingested particle with a lysosome having hydrolytic enzymes.

phagolysosome

a phagocytosed substance is initially engulfed by the cell to form from an invagination of a small region of the cell membrane a phagocytic vacuole, which then fuses with a lysosome to form a phagolysosome within which the lysosomal enzymes are released and other killing mechanisms are activated and the phagocytosed material is degraded.
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References in periodicals archive ?
But the assay is semi--predictive, it neither tests for penetration of the compound into the host cell nor for activity in the peculiar environment of the macrophage phagolysosome.
Lysosomal granules also fuse with cytoplasmic phagosomes to discharge lysozyme into phagolysosomes for killing or digesting trapped microorganisms.
As a next step, we are currently using Caprion's CellCarta platform to identify all the proteins involved in the pathway, from phagosome formation to their transformation into phagolysosomes, the process required to kill pathogens and initiate an efficient immune response.
In all fixed samples, the following details were evaluated separately: nuclear and nucleolar preservation; chromatin pattern and details; mitosis and chromosomes, if present in the metaphase; cytoplasmic details, such as phagolysosomes in the alveolar macrophages; and mucin in mucinous adenocarcinomas.
Despite this battery of defense mechanisms, several bacteria and parasitic species survive and even multiply within macrophage phagolysosomes (2,3).
After internalization of bacteria, the endosome ceases to mature and does not accumulate markers of late endosomes or phagolysosomes (27).
Phagolysosomes that are unable to digest their contents form the pathognomonic MG bodies.
Some lamellated phagolysosomes or autolysosomes were also seen with variably electron-dense material.
Q fever is a worldwide zoonosis caused by Coxiella burnetii, an obligate intracellular bacteria which lives the phagolysosomes of the host cell.
Electron microscopy has shown curved membrane-bound phagolysosomes containing whorled and parallel lamellar phospholipids in the histiocytes.
We can hypothesize that readily water-soluble metals induce acute effects, whereas less soluble metals on PM collected within phagolysosomes can slowly leach off and produce long-term health effects.