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phagolysosome

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phag·o·ly·so·some (fg-ls-sm)
n.
A cellular body that is formed by the union of a phagosome or ingested particle with a lysosome that contains hydrolytic enzymes.

phagolysosome,
a cytoplasmic body formed by the fusion of a phagosome, or ingested particle, with a lysosome containing hydrolytic enzymes. The enzymes digest most of the material within the phagosome.

phagolysosome
a phagocytosed substance is initially engulfed by the cell to form from an invagination of a small region of the cell membrane a phagocytic vacuole, which then fuses with a lysosome to form a phagolysosome within which the lysosomal enzymes are released and other killing mechanisms are activated and the phagocytosed material is degraded.


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Acidic pH, as in the phagolysosome of alveolar macrophages, dissolves manganese oxide, resulting in increased levels of blood-borne nonparticulate Mn.
Lysosomal granules also fuse with cytoplasmic phagosomes to discharge lysozyme into phagolysosomes for killing or digesting trapped microorganisms.
It is conceivable that the increased molecular polarity provided by the additional hydroxy groups lowered the permeability of D6 compounds through the plasma and phagolysosome membranes of the macrophages.
 
 
 
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