phagocytic disorder

phagocytic disorder

Phagocytic disease Immunology Any rare qualitative disorder of phagocytic WBCs, which may be familial and accompanied by generalized metabolic dysfunction; the  prototypic PD is chronic granulomatous disease. Cf Chronic granulomatous disease. Cf Histiocytic diseases.

Phagocytic Disorders

Structural & functional defects

• Alder-Reilly anomaly

•  Chédiak-Higashi anomaly

•  Familial vacuolization of leukocytes (Jordan's anomaly)

•  May-Hegglin anomaly

•  Pelger-Huët anomaly

•  Pseudo- (or acquired) Pelger-Huët anomaly

•  Hereditary giant neutrophilia

•  Hereditary hypersegmentation of neutrophilic nuclei

Functional defects–without structural changes

•  Chronic granulomatous disease

•  Myeloperoxidase deficiency

•  CD11/CD18 adhesive protein deficiency

•  Other enzyme defects