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phage display

   Also found in: Wikipedia 0.01 sec.
phage display
n.
A technique using recombinant DNA technology to create bacteriophages with a desired peptide embedded in the surface of their protein shells. Agonists and antagonists of the target peptide can then be identified experimentally, enabling the engineering of antibodies and development of new drugs.


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USDA-ARS microbiologists and chemists have employed phage display to isolate an antibody fragment that binds specifically to L.
More in detail, during the proposed project we pursued the following two aims: Aim 1) production of phage display antibody libraries from a patient with gluten-ataxia and isolation of anti-TGAse2 and anti-brain reactive autoantibodies; Aim 2) assessment of the effects of passive transfer of purified phage autoantibodies in vivo (creation of different animal models of gluten ataxia).
This updated sixth edition contains many new references, and features information on FRET, in vitro Tn5 transposition, Pyrosequencing, and phage display.
 
 
 
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