peroneal muscular atrophy


Also found in: Dictionary, Thesaurus, Legal, Acronyms, Encyclopedia.
Related to peroneal muscular atrophy: peroneal muscles

atrophy

 [at´ro-fe]
1. decrease in size of a normally developed organ or tissue; see also wasting.
2. to undergo or cause such a decrease. adj., adj atroph´ic.
acute yellow atrophy massive hepatic necrosis.
circumscribed cerebral atrophy pick's disease.
disuse atrophy atrophy of a tissue or organ as a result of inactivity or diminished function.
gyrate atrophy of choroid and retina a rare hereditary, slowly progressive atrophy of the choroid and pigment epithelium of the retina; inherited as an autosomal recessive trait.
juvenile spinal muscular atrophy Kugelberg-Welander syndrome.
Leber's optic atrophy Leber's optic neuropathy.
lobar atrophy pick's disease.
myelopathic muscular atrophy muscular atrophy due to lesion of the spinal cord, as in spinal muscular atrophy.
olivopontocerebellar atrophy any of a group of progressive hereditary disorders involving degeneration of the cerebellar cortex, middle peduncles, ventral pontine surface, and olivary nuclei. They occur in the young to middle-aged and are characterized by ataxia, dysarthria, and tremors similar to those of parkinsonism.
peroneal atrophy (peroneal muscular atrophy) progressive neuromuscular atrophy.
progressive neuromuscular atrophy hereditary muscular atrophy beginning in the muscles supplied by the fibular (peroneal) nerves, progressing slowly to involve the muscles of the hands and arms. Called also peroneal or peroneal muscular atrophy and Charcot-Marie-Tooth disease.
senile atrophy the natural atrophy of tissues and organs occurring with advancing age.
spinal muscular atrophy progressive degeneration of the motor cells of the spinal cord, beginning usually in the small muscles of the hands, but in some cases (scapulohumeral type) in the upper arm and shoulder muscles, and progressing slowly to the leg muscles. Called also Aran-Duchenne disease, Cruveilhier's disease, and Duchenne's disease.
subacute yellow atrophy submassive necrosis of the liver associated with broad zones of necrosis, due to viral, toxic, or drug-induced hepatitis; it may have an acute course with death from liver failure occurring after several weeks, or clinical recovery may be associated with regeneration of the parenchymal cells.

per·o·ne·al mus·cu·lar at·ro·phy

a generic title for at least three distinct hereditary neuromuscular disorders, all of which share the common features of pes cavis and marked wasting of the more distal portion of the limbs, particularly the peroneal muscle groups (resulting in the characteristic "stork legs"). Included in this designation are hereditary motor and sensory neuropathy, type I (formerly known as Charcot-Marie-Tooth, type I, or the hypertrophic type of peroneal muscular atrophy); hereditary and motor sensory neuropathy, type II (formerly known as Charcot-Marie-Tooth, type II, or the neuronal type of peroneal muscular atrophy); and distal hereditary motor neuronopathy (formerly known as Charcot-Marie-Tooth, type III, the spinal type of peroneal muscular atrophy, or distal spinal muscular atrophy).

peroneal muscular atrophy

n.
Charcot-Marie-Tooth disease.

peroneal muscular atrophy

symmetric weakening or atrophy of the foot and the ankle muscles and hammer toes. This disease is a dominantly inherited condition that occurs in a hypertrophic neuropathy form or in a neuronal form. The hypertrophic neuropathy form results in demyelination of nerve fibers and characteristic onion bulb formations. Affected individuals usually have high plantar arches and an awkward gait caused by weak ankle muscles. In the neuronal form this condition usually starts in the second decade of life and causes muscle weaknesses similar to those associated with the hypertrophic neuronal form. Both forms of the disease may also involve mild sensory loss in the lower limbs. Affected individuals may be helped by corrective surgery and leg braces that stabilize weak ankle joints.

per·o·ne·al mus·cu·lar at·ro·phy

(per'ŏ-nē'ăl mŭs'kyū-lăr at'rŏ-fē)
A group of familial peripheral neuromuscular disorders, sharing the common feature of marked wasting of the distal parts of the limbs, particularly the peroneal muscle groups, resulting in "stork legs."
Synonym(s): Charcot-Marie-Tooth disease.

peroneal muscular atrophy

A rare genetic muscle disorder featuring wasting of the muscles of the extremities of the limbs. The foot and calf muscles waste leaving the upper muscles intact so that the legs come to resemble inverted bottles. The arms may be similarly affected. Progression is slow and although walking is affected, severe disability is rare. There is no effective treatment. Also known as Charcot-Marie-Tooth disease. (Jean-Martin Charcot, 1925–93, French neurologist; Pierre Marie, 1853–1940, anatomist, neurologist, painter, sculptor and pupil of Charcot; and Howard Henry Tooth, 1856–1926 English neurologist, who described the condition independently of the Frenchmen).

Charcot,

Jean Martin, French neurologist, 1825-1893.
Charcot arteries - any one of a variety of small cerebral arteries. Synonym(s): lenticulostriate arteries
Charcot arthritis
Charcot arthropathy
Charcot bath - for patients with arterial disorders.
Charcot change
Charcot disease - Synonym(s): Lou Gehrig disease
Charcot fever - Synonym(s): Charcot intermittent fever
Charcot gait - the gait of hereditary ataxia.
Charcot intermittent fever - fever, chills, right upper quadrant pain, and jaundice associated with intermittently obstructing common duct stones. Synonym(s): Charcot fever
Charcot joint - a neuropathic arthropathy that occurs with tabes dorsalis (tabetic neurosyphilis). Synonym(s): tabetic arthropathy
Charcot laryngeal vertigo - fainting as a result of a coughing spell, most often occurring in heavy-set male smokers with chronic bronchitis. Synonym(s): Charcot vertigo; tussive syncope
Charcot spine
Charcot syndrome - a condition caused by ischemia of the muscles. Synonym(s): intermittent claudication
Charcot triad - (1) in multiple (disseminated) sclerosis, the three symptoms: nystagmus, tremor, and scanning speech; - (2) combination of jaundice, fever, and upper abdominal pain that occurs as a result of cholangitis.
Charcot vertigo - Synonym(s): Charcot laryngeal vertigo
Charcot-Böttcher crystalloids - spindle-shaped crystalloids found in human Sertoli cells.
Charcot-Leyden crystals - crystals found in the sputum in bronchial asthma. Synonym(s): asthma crystals; Charcot-Neumann crystals; Charcot-Robin crystals; Leyden crystals
Charcot-Marie-Tooth disease - a group of three familial peripheral neuromuscular disorders, sharing the common feature of marked wasting of the more distal extremities. Synonym(s): peroneal muscular atrophy; Tooth disease
Charcot-Neumann crystals - Synonym(s): Charcot-Leyden crystals
Charcot-Robin crystals - Synonym(s): Charcot-Leyden crystals
Charcot-Weiss-Baker syndrome - stimulation of a hyperactive carotid sinus, causing a marked fall in blood pressure. Synonym(s): carotid sinus syndrome
Charcot-Wilbrand syndrome - inability to recognize objects by sight, usually caused by bilateral parieto-occipital lesions.
Erb-Charcot disease - see under Erb

disease

pathogenic entity characterized by an identifiable aetiological agent, group of signs and symptoms and/or consistent anatomical alterations; see syndrome