pernicious


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Related to pernicious: pernicious anemia, wangle

pernicious

 [per-nish´us]
tending to a fatal outcome.
pernicious anemia a type of megaloblastic anemia seen most often in older adults, caused by lack of intrinsic factor, which normally is produced by the stomach mucosa. The deficiency results in inadequate and abnormal formation of erythrocytes, leukocytes, and platelets, with failure to absorb vitamin B12. Some patients show only mild symptoms and are not particularly aware of the illness; in others it becomes very serious and if untreated can lead to permanent neurologic impairment and even death. It may be caused by deficient vitamin B12 intake, impaired absorption due to intrinsic factor deficiency or intrinsic intestinal disease or increased requirements and impaired utilization.
Symptoms. A pale, colorless, or lemon-yellow complexion is typical. jaundice also occurs, with soreness and reddening of the tongue, difficulty in swallowing, and digestive disturbances such as diarrhea. Other symptoms may include fatigability, heart palpitation, and dyspnea. Changes in the nerves and spinal cord may produce numbness and tingling in the fingers and toes, and the gait may become unsteady; involvement of the nerves can be avoided if the condition is detected and treated in the early stages. Laboratory tests reveal abnormalities in the erythrocytes in the blood and in the bone marrow. Gastric analysis shows an absence of hydrochloric acid and perhaps even an absence of gastric juice.
Treatment. Pernicious anemia is successfully treated by regular injections of vitamin B12, given several times a week at first and monthly after the condition has been brought under control. This treatment must be lifelong to prevent relapse. The injections do not cure the disease but arrest it by providing the body directly with the necessary vitamin that it fails to absorb from the digestive tract. Special diets, liver extract, and other medications taken by mouth usually are not required since the basic defect is not dietary deficiency but improper use of food ingested. The etiology of pernicious anemia is unknown although there appears to be an autoimmune component, as anti–intrinsic factor antibodies are often found. For patient care, see also anemia.

per·ni·cious

(per-nish'ŭs),
Destructive; harmful; denoting a disease of severe character and usually fatal without appropriate treatment.
[L. perniciosus, destructive, fr. pernicies, destruction]

pernicious

/per·ni·cious/ (per-nish´us) tending toward a fatal issue.

pernicious

[pərnish′əs]
Etymology: L, perniciosus, destructive
potentially injurious, destructive, or fatal unless treated, such as pernicious anemia.

pernicious

adjective Bad/not real good

per·ni·ci·ous

(pĕr-nish'ŭs)
Destructive; harmful; denoting a disease of severe character and usually fatal without appropriate treatment.
[L. perniciosus, destructive, fr. pernicies, destruction]

per·ni·ci·ous

(pĕr-nish'ŭs)
Destructive; denoting a disease of severe character and usually fatal without appropriate treatment.
[L. perniciosus, destructive, fr. pernicies, destruction]

pernicious

tending to a fatal issue.

pernicious anemia
a form of anemia in humans caused by a genetically determined lack of the intrinsic factor, which normally is produced by the stomach mucosa. The deficiency results in inadequate and abnormal formation of erythrocytes, and failure to absorb vitamin B12. Not reported in animals.
References in periodicals archive ?
Detecting the presence of intrinsic factor autoantibodies in patients with vitamin B12 deficiency is considered fairly diagnostic of chronic gastritis and pernicious anemia (1) as it is rare to find intrinsic factor antibodies associated with other conditions (2).
The failure marked the problem of King's later years, a difficulty in making nonviolent tactics work with allies less unified than the fight-to-vote-seeking Southern sharecroppers and against an enemy less obviously pernicious than Bull Connor.
Although he admirably exemplified the Protestant penchant for Greek studies, Sponde was also well aware that his Homeric enthusiasm could be construed by some of his rigorist coreligionists as a pernicious diversion from Calvinist faith and from the study of the Bible.
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Osama bin Laden, who has said that all American citizens are legitimate targets of holy warriors, represents a pernicious development in the world not only of Islam but also of Islamic fundamentalism.
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CAMERON: It's demonstrable, pernicious, willful, distorted untruthfulness.