N-methyl-D-aspartate and muscarinic systems participate in object recognition in rats.
These non-spatial learning and physical activity-induced alterations were observed in the perirhinal
cortex (CRUZ et al.
The different effects on recognition memory of perirhinal
kainate and NMDA glutamate receptor antagonism: implications for underlying plasticity mechanisms.
Complete anterograde amnesia, like that of HM, involves not only the hippocampus, but also the cortical areas around the hippocampus, the entorhinal, perirhinal
, and parahippocampal cortices.
And the perirhinal
cortex, once thought to be used mainly for memory, seems to be a place where this coalescing happens, the researchers propose.
However, most researchers believe that vestibular input to the hippocampus is derived from thalamic projections to the parietal cortex, which then projects fibres back to the hippocampus via the perirhinal
and entorhinal cortices.
Analysing MRI scans of VJ's brain, Maeder found very severe atrophy (wasting away of brain tissue) in the hippocampi, while the adjacent area of the brain, known as the perirhinal
cortex, was relatively spared from damage.
damage extended to the entorhinal and perirhinal
Their results showed that two main areas of the MTL are involved in integrating "what" and "when": the hippocampus and the perirhinal
Neither 'object-in-place' or 'temporal order recognition' memories could be formed if communication between the hippocampus and either the perirhinal
cortex, or the medial prefrontal cortex, was broken.
Washington, Dec 16 (ANI): Researchers at the UC Davis Center for Mind and Brain have found that a small area deep in the brain called the perirhinal
cortex is critical for forming unconscious conceptual memories.
Lesions on the rat perirhinal
cortex spare the acquisition of a complex configural visual discrimination yet impair object recognition.