The different effects on recognition memory of perirhinal kainate and NMDA glutamate receptor antagonism: implications for underlying plasticity mechanisms.
Glutamate receptors in perirhinal cortex mediate encoding, retrieval, and consolidation of object recognition memory.
Complete anterograde amnesia, like that of HM, involves not only the hippocampus, but also the cortical areas around the hippocampus, the entorhinal, perirhinal, and parahippocampal cortices.
Two-thirds of the cortical input to entorhinal cortex comes from perirhinal and parahippocampal cortices.
And the perirhinal
cortex, once thought to be used mainly for memory, seems to be a place where this coalescing happens, the researchers propose.
cortex appeared to integrate information about what and when by signaling whether a particular item was shown first or second in the series.
Neuroscientists had previously thought the same was true for the perirhinal cortex, which is located immediately next to the hippocampus.
Wang and colleagues carried out memory tests on people diagnosed with amnesia, who had known damage to the perirhinal cortex or other brain areas.