perinuclear


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per·i·nu·cle·ar

(per'i-nū'klē-ăr),
Surrounding a nucleus.
Synonym(s): circumnuclear

perinuclear

/peri·nu·cle·ar/ (-noo´kle-ar) near or around a nucleus.

perinuclear

(pĕr″ĭ-nū′klē-ăr) [″ + L. nucleus, a kernel]
Around a nucleus.
References in periodicals archive ?
T-cell lymphoma in an unusual, dotlike perinuclear pattern localized to the Golgi zone, (3) subcutaneous panniculitis-like T-cell lymphoma may have abundant histiocytes, (7,8,10,15) making assessment of the neoplastic cells challenging.
46) Localization of cPGES in the cytosol may allow coupling with proximal COX-1 in the endoplasmic reticulum (ER) in preference to distal COX-2 in the perinuclear envelope, although other regulatory mechanisms could be involved.
The distinguishing features of HTT in cytology are the radial arrangement of cohesive tumour cells surrounding the hyaline material, whirling parallel arrays, vague, curved nuclear palisading, spindled or elongated cells, ill-defined cell borders, faintly stained, abundant, filamentous cytoplasm, frequent intranuclear grooves, pseudoinclusions, perinuclear halo, haemorrhagic background, lack of papillary architecture and sheet-like arrangement.
These infiltrated cells possess ovoid nuclei, some with dispersed chromatin and some presenting anisonucleosis, perinuclear cytoplasmic vacuolization and possible Bowenoid transformation, which may suggest a viral etiology.
All virological and serological investigations, including HIV, hepatitis B surface antigen, hepatitis C virus antibodies, antinuclear antibodies, rheumatoid factor, a VDRL test, and perinuclear and cytoplasmic ANCA were negative.
The skin biopsy showed a predominance of folliculotropism (Figure 2c), compared to a less-remarkable epidermotropism, with intraepidermal clusters of atypical lymphocytes larger than benign recruited dermal lymphocytes, as well as perinuclear vacuolization seen in the patch- and plaque-stage of MF (H&E stain, 2a, b.
There was mild anisokaryosis, and perinuclear vacuoles containing lipofuscin granules were widespread.
The vesicular compartment is organized as a collective unit wherein the bulk of endosomes derived from disparate origins resides in a cloud in the perinuclear region and extends outwards to include quickly moving vesicles in the periphery.
Higher magnification showed formation of circular zone of peripherin staining around the nucleus (similar to perinuclear ring) [Figure 3D].
To exclude vasculitis perinuclear anti-neutrophil cytoplasmic antibody (p-ANCA), cytoplasmic antineutrophil cytoplasmic antibodies (c-ANCA) and anti neutrophil antibodies titres can be obtained.