The rate was regressed separately on predictors, including diagnosis, number of biopsies, Gleason grade, extent of cancer, and presence of perineural invasion in cancer cases, by using Poisson regression with a log-linear link function to account for nonnormal distribution of rates.
A recent study of 135 patients with skin carcinomas with evidence of perineural spread showed that after radiation therapy, the 5-year local control of patients with clinical, or macroscopic, perineural invasion was only 55% (Head Neck 2003;25: 1027-33).
Pleomorphic adenomas (1) are nodular, (2) lack perineural invasion, (3) tend to contain plasmacytoid cells and a myxoid-chondroid matrix, and (4) usually exhibit strong immunoreactivity to glial fibrillary acidic protein.
Prognostic significance of preoperative factors in localized prostate carcinoma treated with radical prostatectomy: importance of percentage of biopsies that contain tumor and the presence of biopsy perineural invasion.
The tumour also showed extensive lymphatic and perineural invasion with tumour in the lymphatics around the left seminal vesicle, but not involving the seminal vesicles, prostate or urethra; and 5 of the 17 lymph nodes were positive for TCC.
16) The presence of any tumor with a Gleason pattern of 4 and perineural invasion is predictive of significant tumor burden and possible extraprostatic extension on RP; thus, this pattern may be a contraindication for surveillance.