This device is not dependent on an adequate perfusion rate
or pulse rate.
50 and 250 mg/kg/day of Gl-PS treatment significantly increased the mean perfusion rate
around the wound in diabetic mice.
The authors conclude that findings are consistent with size-dependent transfer of nanomaterials across human placentas, but they acknowledge that the model involved high-dose exposures over a period of a few hours and that the perfusion rate
was representative of placental perfusion late in pregnancy.
Ideally, the lung's transfer rate and the perfusion rate
, as described above, should be the same throughout the lung but, in reality, the rates are different in various sections of the lung due to the dynamic conditions of respiration, blood flow, effects of gravity and differences in Dm, Qc, and [theta].
Retrograde CS perfusion rate
was kept between 400-500 ml/min and perfusion pressure kept between 50-60 mmHg.
A further limitation of the model is that the perfusion rate
measured in the explant represents only the late phase of pregnancy, for which the thickness of the barrier layer between the maternal and the fetal circuit is reduced and the number of fetal capillaries is increased (Enders and Blankenship 1999).
The study results demonstrated that patients receiving 10 to 15 million cells (n=9) experienced significant improvement in resting perfusion rates
at six months as compared to patients receiving 5 million cells (n=6) and control (n=15), as measured by the SPECT total severity score, (-256 versus +13, p=0.
Therefore, blood flow perfusion rates
(a measure of microcirculatory activity) were assessed before and after treatment in both study groups.
These include the addition of growth factors, adjusting medium perfusion rates
and optimizing the concentration of the starting cell sample.
In addition, Hemedex seeks to form partnerships with segment leading healthcare companies that have critical mass in other target markets, and which sell devices that are synergistic with the ability to quantify perfusion rates
in soft tissue.