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perforin

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perforin
a protein in cytotoxic T lymphocytes that creates transmembrane pores that act as ion channels in the target cell. Structurally and chemically related to C9 protein of complement which performs a similar function.


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Tip 4c reaksiyonda ise CD 8 pozitif sitotoksik T hucreler perforin ve granzim B gibi enzimler salarak direk hucre lizisi yapmaktadir.
12) Other cytotoxic T- lymphocyte mechanisms are regarded to play a role as well, such as Fas/Fas ligands or granulysis (a protein, discovered in granules of cytotoxic T-lymphocytes, which in combination with perforin reduces the vitality of a broad spectrum of pathogenic bacteria and through which T- cells directly contribute to the immunity against intracellular pathogens).
Lysis of infected epithelial cells is mediated by exocytosis granules containing perforin and granzymes (18,19).
 
 
 
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