perforin


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per·for·in

(per'fōr-in),
A protein found in the cytoplasmic granules of both T-cytotoxic lymphocytes and natural killer cells. This protein is implicated in target cell lysis by the above cells.
[L. per-foro, to bore, pierce, + -in]

perforin

(pûr′fər-ĭn)
n.
A protein released by killer cells and natural killer cells that causes lysis of target cells by forming pores in their membranes.

per·for·in

(pĕr'fŏ-rin)
A protein found in the cytoplasmic granules of both T-cytotoxic lymphocytes and natural killer cells, implicated in target cell lysis.
[L. per-foro, to bore, pierce, + -in]

perforin

A molecule produced by cytotoxic T cells and natural killer cells which forms a pore in the membrane of the attacked cell resulting in LYSIS and cell death. A similar process can be brought about by COMPLEMENT.

perforin

see KILLER T-CELL.

perforin

a protein in cytotoxic T lymphocytes that creates transmembrane pores that act as ion channels in the target cell. Structurally and chemically related to C9 protein of complement which performs a similar function.
References in periodicals archive ?
The investigators also observed that the cell-killing substances granzyme B and perforin (both necessary to kill targeted cells and viruses) produced by activated CD8+ killer T cells were present in quantities and characteristics similar to those of long-term non-progressors.
A defect in CTL and NK cell-directed apoptosis (via perforin and granzyme) of these activated clonal lymphocytes once the stimulus has been removed forms the common pathway of familial and acquired HLH.
Nicholl said: "It is critical that both proteins, perforin and granzyme B, are present in order to kill the tumour cells, and we found that the resveratrol helped to increase their activity in prostate tumour cells.
A perforin knock-out mouse model with hemophagocytosis indicates a pivotal role of interferonγ.
They don't have past data because they didn't originate the loans, and as a result they cannot perforin future calculations," says Wall.
Although not considered a module, the central portion of each protein (~ 40 kDa) is designated MACPF to emphasize its conservation among the MAC proteins and its sequence similarity to perforin, a 70 kDa pore-forming protein released from secretory granules of cytotoxic T lymphocytes.
The two he finds most plausible are that etanercept is less able to penetrate tuberculosis granulomas than are the monoclonal antibody TNF inhibitors, as shown in a mouse model, and the possibility-unproven-that etanercept might cause less downregulation of CDS cells producing the antimicrobial peptides perforin and granulysin, which are directed against Mycobacterium tuberculosis.
Tc cell would bind to target cells through Fas and Fas ligand and secrete perforin and granzyme that induces apoptosis in target cells.
Neem leaf glycoprotein induced perforin mediated tumor cell killing by T and NK cells through differential regulation of IFN[gamma] signaling.
Procrastination and intentions to perforin health behaviors: The role of self-efficacy and the consideration of future consequences.
For a reference guide on this topic, consider Fiduciary/Trust Accounting: A Comprehensive Practice Guide (AICPA 2008) or Practice Guide for Fiduciary (Trust) Accounting: A Guide for Accountants Who Perforin Fiduciary Accounting Services (AICPA 2007).