is a private company focused on developing the use of peptidomimetics
as a novel approach to treating ophthalmic diseases with high unmet medical needs.
1) is a feasible structural modification of biologically active peptides for obtaining peptidomimetics
with an increased effective lifetime in biological systems [1, 2].
After introducing the paradigm, the book covers methodology useful to diversity-oriented synthesis including multicomponent and "domino" strategies, cycloadditions, phosphine organocatalysis, peptidomimetics
, solid-phase synthesis, and macrocycles.
Beginning with a comprehensive chapter outlining computational methods in peptide and protein design, it goes on to explore peptidomimetics
, design of cyclic peptides, the role of carbohydrates in the process of design, and de novo methods.
Keeping close ties with Ukrainian academic research centers, Enamine explores a variety of prospective topics in contemporary organic chemistry, such as assymmetric synthesis, synthesis of fluorescent dyes and peptidomimetics
, and supports other projects aimed at the development of fundamental research in organic chemistry.
The Company also has a rich pipeline of small molecule compounds in preclinical development, consisting primarily of new chemical entities based on 2-methoxyestradiol-related structures (steroidal and non-steroidal analogs) and chemically-derived small molecules from peptides -- peptidomimetics
The company has distinguished itself as an early innovator of combinatorial chemistry techniques for drug discovery and as one of the world's largest manufacturers of custom peptides, peptidomimetics
and small molecule libraries.
Treco will present "Direct selection of cyclic peptidomimetics
from in vitro display libraries" at TIDES, the Oligonucleotide and Peptide Research, Technology and Product Development Conference on Wednesday, May 23, 2012, at 10:00 am PT at the Mandalay Bay Resort & Casino in Las Vegas, NV.
We proposed the preparation of a novel and diverse library of conformationally constrained peptidomimetics
containing quaternary stereocenters derived from B/C/P approach with increased biological relevance.
The chapter entitled, "Microwave-Enhanced Synthesis of Peptides, Proteins and Peptidomimetics
," was authored by Jonathan M.
At present his main research fields are design, synthesis, and testing of biomimetic organic compounds and peptidomimetics
Valentis' core technologies include multiple gene delivery and gene expression systems and PEGylation technologies designed to improve the safety, efficacy and dosing characteristics of genes, proteins, peptides, peptidomimetics
, antibodies, replicating and non replicating viruses and liposomes.