peptidomimetics

peptidomimetics

(pĕp″tĭ-dō-mĭ-mĕt′ĭks, pĕp-tīd′ō-mī-) [″ + ″]
The synthetic alteration of a natural peptide to make a new molecule that works in a specific biological or therapeutic application.
References in periodicals archive ?
The prodrug approach, structural modifications, and peptidomimetics, targeting the membrane transporters, receptors, and tissues, are the basic chemical modification approaches for protein drugs (18, 20).
This study found that the androgen receptor signaling could be disrupted using a novel class of drugs called peptidomimetics.
Umashankar Vetrivel, Priya Sankar, Naveen Kumar Nagarajan, Gurunathan Subramanian (2009) Peptidomimetics Based Inhibitor Design for HIV-1 gp120 Attachment Protein.
Biological activities of the natural imidazole-containing peptidomimetics n-acetylcarnosine, carcinine and L-carnosine in ophthalmic and skin care products.
The applications of non-classical bioisosterism have also been reported in a number of areas of pharmacology including adrenergic and anti adrenergic drugs [28, 30-31] , several NSAID classes like aryl acetic acid derivatives [32], cetroplac, tolmetin, indomethacin, etodolac [5], antibacterial drugs [33] , antidepressant of morpholine class [34] , neuropeptide substance P antagonists (NK1 antagonists) [35], cholinergic (muscarinic type) agonists [36], GABA modulators like muscimol, thiomuscimol, isomuscimol as agonists [37-38], peptidomimetics [39], diuretics like ethacrinic acid [5] and 5-hyderoxy tryptamine (5-HT1A;1D) agonists like naratryptan and sumatryptan for acute attack of migraine [40].
After introducing the paradigm, the book covers methodology useful to diversity-oriented synthesis including multicomponent and "domino" strategies, cycloadditions, phosphine organocatalysis, peptidomimetics, solid-phase synthesis, and macrocycles.
Peptidomimetics play a central role in the treatment and management of a number of diverse conditions.
These structures are termed as peptidomimetics which are to mimic peptides in the anticipation of attaining more bioavailable units (6).
Phage-borne peptidomimetics accelerate the development of polyclonal antibody-based heterologous immunoassays for the detection of pesticide metabolites.
Peptidomimetics and hydroxamic acid-based inhibitors have been developed that display inhibitory effects (149-152) in the high nm range for the light chain of the BoNT serotype A.
Beginning with a comprehensive chapter outlining computational methods in peptide and protein design, it goes on to explore peptidomimetics, design of cyclic peptides, the role of carbohydrates in the process of design, and de novo methods.