Successful treatment of Colombian cutaneous leishmaniasis with four infections of pentamidine
The relationship between extrapulmonary pneumocystosis and aerosolized pentamidine
is somewhat complex.
At that time, it was not yet known that nebulised pentamidine
was both a cytotoxic drug and one that often induced coughing and therefore should be administered in a negative-pressure environment, but it was prescribed to the majority of our patients, and we administered it in groups of three to six patients.
The drug of choice for treating the hemolymphatic stage of Gambian sleeping sickness is pentamidine
isethionate as it has a cure rate of 93-98%.
initially used as a second-line drug, acquired resistance (25%) even with prolonged dosage (17).
Extrapulmonary infection becomes more evident when prophylaxis is focused on the respiratory tract, and this may explain the correlation with the use of aerosolised prophylactic pentamidine
spironolactone, triamterene, amiloride, ACE inhibitors, ARBs, trimethoprim, pentamidine
, cyclosporine, tacrolimus, heparin)
Targeted at pneumocystis carinii pneumonia (PCP), the largest cause of death in AIDS patients, pentamidine
was approved in 1984.
The compound called pentamidine
carries approval of the U.
Adherence to pentamidine
was assessed by chart review.
If children are unable to tolerate co-trimoxazole, for whatever reason, nebulised pentamidine
is given as a prophylactic agent monthly in the PTC.
Although liposomal amphotericin B is the most often advised treatment for VL currently, our results with meglumine antimonate (MA; glucantime), which began with a dose of 20 mg/kg/day for 3 days, was increased to 30 mg/kg/day for 3 days and/or then increased to 60 mg/kg per day for 2 weeks, for a total of 20 days) followed by pentamidine
isethionate (PI) every other day for a total 15 doses (2.