penicillinase

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Related to penicillinases: cephalosporinase

penicillinase

 [pen″ĭ-sil´ĭ-nās]
an enzyme produced by certain bacteria that inactivates penicillin, so that such bacteria have increased resistance to the antibiotic; a purified form from Bacillus cereus is used in treatment of reactions to penicillin.

pen·i·cil·li·nase

(pen'i-sil'i-nās),
1. Synonym(s): β-lactamase
2. A purified enzyme preparation obtained from cultures of a strain of Bacillus cereus; formerly used to treat slowly developing or delayed penicillin reactions.

penicillinase

/pen·i·cil·lin·ase/ (pen″ĭ-sil´ĭ-nās) a β-lactamase preferentially cleaving penicillin.

penicillinase

(pĕn′ĭ-sĭl′ĭ-nās′)
n.
Any of several beta-lactamase enzymes that cleave the beta-lactam ring in penicillins. Penicillinases are found in many penicillin-resistant bacteria.

penicillinase

[pen′əsil′ənās]
an enzyme elaborated by certain bacteria, including many strains of staphylococci, that inactivates penicillin and thereby promotes resistance to the antibiotic. A purified preparation of penicillinase, derived from cultures of saprophytic spore-forming Bacillus cereus, is used in the treatment of adverse reactions to penicillin. Also called beta-lactamase.

penicillinase

An enzyme present in some bacteria, especially STAPHYLOCOCCI, that inactivates penicillins, by HYDROLYSIS of the beta-lactam bond, so that the organisms possess resistance to the drug. Also known as beta-lactamase.

penicillinase

enzyme inactivating penicillin; produced by some staphylococci

be·ta-lac·ta·mase

(bā'tă lak'tā-mās)
An enzyme produced by many species of bacteria that disrupts the four-membered β-lactam ring of penicillin and cephalosporin groups of antibiotics, destroying their antimicrobial activity.
Synonym(s): penicillinase.

penicillinase

an enzyme produced by bacteria that inactivates penicillin, thus increasing resistance to the antibiotic; a purified form from Bacillus cereus is used in the treatment of reactions to penicillin.
References in periodicals archive ?
Plasmid-mediated resistance to third-generation cephalosporins caused by point-mutations in TEM-type penicillinase genes.
Ertapenem is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.
Enterobacteriaceae, except Salmonella and Klebsiella) Group 2 penicillinases D Staphylococcal A penicillinases;TEM-1, TEM-2, SHV-1 (broadspectrum); TEM and SHV variants (e.

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