penicillamine


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Related to penicillamine: penicillin

penicillamine

 [pen″ĭ-sil´ah-mēn]
a degradation product of penicillin that chelates certain heavy metals; used orally to reduce the blood copper level in Wilson's disease and to promote excretion of cystine in patients with cystinuria or recurrent cystine renal calculus formation, by helping to solubilize cystine. It is also used as a disease-modifying antirheumatic drug in treatment of refractory rheumatoid arthritis.

pen·i·cil·la·mine

(pen'i-sil'ă-mēn),
A degradation product of penicillin; a chelating agent used in the treatment of lead poisoning, hepatolenticular degeneration, and cystinuria, and in the removal of excess copper in Wilson disease.
Synonym(s): β, β-dimethylcysteine

penicillamine

/pen·i·cil·la·mine/ (pen″ĭ-sil´ah-mēn) a degradation product of penicillin that chelates certain heavy metals and also binds cystine and promotes its excretion; used in the treatment of Wilson's disease, cystinuria, recurrent cystine renal calculi, and rheumatoid arthritis.

penicillamine

(pĕn′ĭ-sĭl′ə-mēn′)
n.
A chelating agent, C5H11NO2S, that is a degradation product of penicillin and is used in the treatment of Wilson disease, refractory rheumatoid arthritis, and excess urinary excretion of cystine.

penicillamine

[pen′isil′əmēn]
a chelating agent.
indications It is prescribed for the treatment of Wilson's disease and cystinuria and can be prescribed to bind with and remove heavy metals from the blood when there is poisoning resulting from metals such as copper, lead, mercury, arsenic, and gold (succimer is preferred for lead and mercury toxicity). It is also prescribed as a palliative in the treatment of systemic sclerosis (scleroderma) and rheumatoid arthritis when other medications have failed.
contraindications Known hypersensitivity to this drug or penicillamine-related aplastic anemia prohibits its use. It is not given to patients who are pregnant or who have kidney dysfunction.
adverse effects Among the more serious adverse effects are fever, rashes, and blood dyscrasias. Severe bone marrow depression and immune disorders have been associated with long-term use of this drug. d-penicillamine is less toxic than the l form, and much of the reported toxicity is caused by the use of the l or dl form.

penicillamine

Metabolic disease A drug that removes copper, lead, mercury, and other metals from the body, which inhibit angiogenesis in brain tumors

pen·i·cil·la·mine

(pen'i-sil'ă-mēn)
A degradation product of penicillin; a chelating agent used to treat lead poisoning, hepatolenticular degeneration, and cystinuria.
Synonym(s): β, β-dimethylcysteine.

penicillamine

A drug used to treat severe RHEUMATOID ARTHRITIS not responding to nonsteroidal anti-inflammatory drugs (NSAIDs).

Penicillamine is a CHELATING AGENT and is also used to treat poisoning with metallic salts or disorders such as WILSON'S DISEASE. The drug is on the WHO official list. Brand names are Distamine and Pendramine.

Penicillamine (Cuprimine, Depen)

A drug used to treat medical problems (such as excess copper in the body and rheumatoid arthritis) and to prevent kidney stones. It is also sometimes prescribed to remove excess lead from the body.
Mentioned in: Lead Poisoning

penicillamine

immune-disease modifying drug, used to treat rheumatoid arthritis characterized by troublesome extra-articular features, or those taking high doses of corticosteroids; beneficial effects of medication take 6-12 weeks to show

pen·i·cil·la·mine

(pen'i-sil'ă-mēn)
Degradation product of penicillin used to treat lead poisoning, hepatolenticular degeneration, and cystinuria.

penicillamine, d-penicillamine

a product of penicillin which chelates copper and other metals; used in the treatment of copper accumulation associated with chronic hepatitis, copper-associated hepatopathy of Bedlington terriers, and lead poisoning.
References in periodicals archive ?
Treatment-P1 group" received daily penicillamine 50 mg/kg/day, 7 days before and 4 weeks after administering single-dose bleomycin [18].
Low-dose methotrexate (5 to 15 mg once weekly) is now being used more often, before therapy with gold salts or penicillamine, with improvement in symptoms, although the mechanism of action is debatable.
Penicillamine in ankylosing spondylitis: a double blind placebo controlled trial.
The point is when Penicillamine works for a sufferer, it works wonderfully and I was lucky because it worked for me.
Through our research, we soon learned that penicillamine, the medication Justin was taking, was very dangerous.
Some of these include the new drug Arava and methotrexate, hydroxychloroquine, penicillamine, and gold injections.
A OTHER disease-modifying drugs, such as the gold injections, are penicillamine, sulphasalazine and chloroquine.
Tetracycline and fluoroquinolone antibiotics, iron, digoxin, chlorpromazine and penicillamine, should be taken at least 2 hours before and not less than 6 hours after administration of PREPOPIK to avoid chelation with magnesium.
The possibility of an autoimmune etiology in some patients with IS was suggested by its association with myasthenia gravis, thymoma, Addison's disease, vitiligo, Hashimoto's thyroiditis, vitamin B12 deficiency, coeliac disease, rheumatoid arthritis, and penicillamine treatment (2).
Heterozygotes are asymptomatic but may exhibit hypoceruloplasminemia, increased urinary copper excretion after penicillamine treatment, and a hepatic copper content of 1.
Other rheumatologic medications to avoid in pregnancy are methotrexate, penicillamine, 6-mercaptopurine, and chlorambucil, she continued.
N-acetyl cysteine (NAC) and penicillamine (PEN) have been shown to induce apoptosis in multiple types of human cancer cells; however, the molecular mechanism underlying this activity is unclear.