IRAK1

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IRAK1

A gene on chromosome Xq28 that encodes interleukin-1 receptor (IL1R)-associated kinase 1, one of two putative serine/threonine kinases which associate with IL1R after stimulation. IRAK1 is partially responsible for IL1-induced upregulation of transcription factor NF-kappa B.
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Pelle (above), who now plays for Chinese club Shandong Luneng, refused to shake the hand of coach Giampiero Ventura when he was substituted against Spain on Thursday night.
Pelle, who has already apologised for his tantrum, was taken off on the hour after an ineffective display in the World Cup qualifier which ended in a 1-1 draw on Thursday.
Pelle, known as "Mamma", was serving a 20-year prison sentence for Mafia association, arms and drug trafficking when he slipped out of a hospital in the town of Locri in September 2011, where he was said to be being treated for anorexia.
Pelle - who scored twice for Italy in Euro 2016 - was snapped up by Shandong Luneng in a PS13m deal.
Koeman wanted a reunion with the Southampton striker but Pelle has accepted a lucrative offer from China.
Pelle, who turns 31 on July 15, had only one year remaining on his Southampton deal and had been linked with a move away from St Mary's Stadium during the January transfer window.
Pelle will leave St Mary's this summer but the 30-year-old could be heading to the Far East rather than west London.
He also had a hand in his side's first goal during last week's last-16 victory over Spain, when Pelle got the second.
De Gea pulled off a string of fine saves to deny the likes of Pelle, Emanuele Giaccherini and Eder but Italian class told in the end as they underlined their emergence as genuine contenders to seize the vacated crown.
MATCH FACTS ITALY: Buffon, Barzagli, Bonucci, Chiellini, Florenzi (Darmian 84), Parolo, De Rossi (Thiago Motta 53), Giaccherini, De Sciglio, Pelle, Eder (Insigne 82), Bernardeschi, El Shaarawy, Marchetti.
Buffon rose to the occasion in the dying minutes, denying first Iniesta then Pique before Pelle rounded off a superb individual performance with the goal to send his country through to the last eight.
Pelle ran to the dug-out to celebrate the first of his goals with Koeman, who said: "I had talked to him before about how he had been struggling a bit in scoring goals and it was a great response.