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pegvisomant |
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pegvisomant,
a rarely used miscellaneous agent. indications This drug is used to treat acromegaly in those patients who have an inadequate response to other treatment. contraindications Latex allergy and known hypersensitivity to this drug prohibit its use. pegvisomant Somavert Pharmacologic class: Growth hormone (GH) receptor antagonist Therapeutic class: GH analog Pregnancy risk category B ActionSelectively binds to GH receptors on cell surfaces, where it blocks binding of endogenous GH and interferes with GH signal transduction. This action decreases blood levels of insulin-like growth factor-1 (IGF-1) and other GH-responsive serum proteins. AvailabilitySolution: 10-mg, 15-mg, and 20-mg vials ⊘Indications and dosages ➣ Acromegaly Adults: Initial subcutaneous loading dose of 40 mg, followed by 10 mg/day subcutaneously. May adjust in 5-mg increments after serum IGF-1 measurement q 4 to 6 weeks; don't exceed maximum daily maintenance dosage of 30 mg. Contraindications• Hypersensitivity to drug, its components, or latex (in vial stopper) PrecautionsUse cautiously in: Administration• Reconstitute in vial with 1 ml of sterile water for injection.
Adverse reactionsCNS: dizziness, paresthesia CV: chest pain, hypertension, peripheral edema EENT: sinusitis GI: nausea, diarrhea, abdominal pain Musculoskeletal: back pain Other: infection, pain, injection site reaction, accidental injury, flulike symptoms InteractionsDrug-drug. Insulin, oral hypoglycemics: decreased insulin sensitivity, reduced requirements for these drugs Opioids: increased pegvisomant requirement Drug-diagnostic tests. GH assays: interference with GH measurement Liver function tests: abnormal results Drug-behaviors. Opioid addiction: increased pegvisomant requirement Patient monitoring• Assess liver function tests; watch for signs and symptoms of hepatic dysfunction. Patient teaching• Teach patient proper technique for reconstituting and administering drug subcutaneously. Want to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit the webmaster's page for free fun content. |
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Preliminary clinical data1 suggest that the combined treatment of acromegaly with monthly long-acting somatostatin analogue(s) and weekly subcutaneous pegvisomant administrations is effective, might increase compliance and could greatly reduce the costs of medical treatment in some patients. 252 (17 July 2006) (4) Source: (Alexander L, Clin Endocrinol 12:71-79, 1980 & Bengtsson BA, Acta Med Scan 223:327-335, 1988) (5) Source: IMS MIDAS/Ex-manufactures as a percentage of sales of sustained release formulations of the specific molecules lanreotides, octreotide and pegvisomant -- in class H1C2 for hepatitis-C, -- pegvisomant (Somavert(R)) with Pharmacia Corporation for acromegaly, a disease that produces increased quantities of growth hormone leading to abnormal growth of hands, feet and other areas of the body. |
pegvisomant |
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