The mean number of nights with detected hypoglycemia was 21 (4-42) per patient-year
, or 6% of all nights.
The linearized reoperation rates per patient-year
Comparison of the estimates by individual guideline shows that the practices resulting in the largest patient-year
gains were increasing patient albumin above 40 g/L and reducing facility catheter use to below 10%.
3% per patient-year
(95% confidence interval [CI], 0.
015 cases per patient-year
of exposure to adalimumab, 0.
18 events per patient-year
in the PREPARE cohort and 0.
This analysis focused on participants with a mean 18-year psoriasis history and no NMSC history at enrollment: 2,623 on ustekinumab with 7,900 patient-years
of prospective follow-up, 3,727 on a TNF inhibitor with 10,580 patient-years
of follow-up, and 432 controls on methotrexate with 781 patient-years
The RA clinical development programme has over 20 clinical trials and to-date represents more than 21,100 patient-years
of drug exposure.
In subgroup analyses, the risk of cardiovascular death appeared to be increased in patients on azithromycin who'd had cardiovascular disease, compared with patients on the drug with no history of cardiovascular disease (rates of 10 and 1 cardiovascular death per 1,000 patient-years
, respectively), but the difference did not reach statistical significance.