pathophysiological pain

pathophysiological pain

; second pain; slow pain pain that encourages healing by inducing protective behaviours; it originates from stimulation of high-threshold polymodal nociceptors (free nerve endings, present in all tissues and responsive to mechanical, chemical and thermal stimuli) and is transmitted along slow-conduction C fibres (which also induce emotional and behavioural responses to pain via thalamic connections, and activate inhibitory pain pathways and the release of endogenous opioids)