The cost implication of offering solely passive prophylaxis
during intensive chemotherapy of patients with leukaemia and non-Hodgkin's lymphoma led to discontinuation of this protocol and a recommendation for simultaneous passive and active immunoprophylaxis from the start of such therapy.
Therefore, it should be stressed that passive prophylaxis
alone needs to be administered during the entire course of aggressive chemotherapy.
All infants born to these mothers would have been at high risk of acquiring HBV and should have been offered active immunization with the HBV vaccine, as well as passive prophylaxis