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lipodystrophy
(redirected from partial lipodystrophy)

   Also found in: Dictionary/thesaurus, Encyclopedia, Wikipedia 0.01 sec.
lipodystrophy /lipo·dys·tro·phy/ (-dis´tro-fe) any disturbance of fat metabolism.
congenital generalized lipodystrophy , congenital progressive lipodystrophy total l.
generalized lipodystrophy  total l.
partial lipodystrophy , progressive lipodystrophy progressive and symmetrical loss of subcutaneous fat from the parts above the pelvis, beginning with facial emaciation and progressing downward, giving an apparent and possibly real accumulation of fat about the thighs and buttocks.
total lipodystrophy  a recessive condition marked by the virtual absence of subcutaneous adipose tissue, macrosomia, visceromegaly, hypertrichosis, acanthosis nigricans, and reduced glucose tolerance in the presence of high insulin levels.

lip·o·dys·tro·phy (lp-dstr-f)
n.
Defective metabolism of fat.

lipodystrophy
[lip′ōdis′trəfē]
Etymology: Gk, lipos + dys, bad, trophe, nourishment
any abnormality in the metabolism or deposition of fats. Kinds of lipodystrophy are congenital total lipodystrophy, familial partial lipodystrophy, insulin lipodystrophy membranous lipodystrophy, and progressive lipodystrophy.

lipodystrophy [lip″o-dis´tro-fe]
1. any disturbance of fat metabolism.
2. a group of conditions due to defective metabolism of fat, resulting in absence of subcutaneous fat; they may be congenital or acquired and partial or total. (See Atlas 2, Part F.)
congenital generalized lipodystrophy an autosomal recessive condition marked by the virtual absence of subcutaneous adipose tissue, large body size, splenomegaly, hirsutism, acanthosis nigricans, and reduced glucose tolerance in the presence of high insulin levels.
intestinal lipodystrophy former name for Whipple's disease.
partial lipodystrophy a condition seen mainly in females in the first decade of life, characterized by symmetrical loss of subcutaneous fat, usually beginning on the face and gradually extending to the chest, neck, back, and upper limbs; this gives the lower part of the body an apparent, and possibly real, adiposity of the buttocks and lower limbs. Some affected patients develop insulin-resistant diabetes mellitus, triglyceridemia, and renal disease.
progressive lipodystrophy progressive and symmetrical loss of subcutaneous fat from the parts above the pelvis, facial emaciation, and abnormal accumulation of fat about the thighs and buttocks.
total lipodystrophy an autosomal recessive disorder occurring mainly in females, characterized by a generalized loss of subcutaneous fat and extracutaneous adipose tissue, present at birth or appearing later in life, and associated with hepatomegaly with abdominal protuberance, hypoglycemia and insulin-resistant nonketotic diabetes, hyperlipemia, marked elevation of the basal metabolic rate, accelerated somatic growth, advanced bone age, acanthosis nigricans and hirsutism.

lipodystrophy
(lip´ōdis´trfē),
n an abnormality in the metabolism or deposition of fats.

lipodystrophy
any disturbance of fat metabolism.

porcine cerebrospinal lipodystrophy


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In 2002, a mutation called PPAR-gamma was linked to another type of familial partial lipodystrophy.
Previous studies mapped mutations in a family prone to partial lipodystrophy to a region on chromosome 1 containing about 120 genes.
 
 
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