paroxysmal nocturnal haemoglobinuria

paroxysmal nocturnal haemoglobinuria

A rare disease featuring episodic HAEMOLYSIS that occurs during the night when a decline in the pH of the blood triggers activation of complement components. The release of haemoglobin into the blood causes the morning urine to be black. The condition also features thrombosis and this may involve the hepatic vein causing the BUDD-CHIARI SYNDROME.
References in periodicals archive ?
John Duggan, 33, was initially refused Soliris by HSE bosses to fight Paroxysmal Nocturnal Haemoglobinuria with which he was diagnosed in 2010.
2] Hypercoagulation disorders such as systemic lupus erythematosus, antiphospholipid syndrome, the presence of factor V Leiden, paroxysmal nocturnal haemoglobinuria, hyperhomocysteinaemia, protein C and S deficiency, and heparin-induced thrombocytopenia are also all reported as risk factors for ovarian vein thrombosis.
The event at Banney Royd raised cash for treatment of Paroxysmal Nocturnal Haemoglobinuria (PNH) at St James's Hospital, Leeds.
Paroxysmal nocturnal haemoglobinuria clones in patients with myelodysplastic syndromes.
Recent developments in the understanding and management of paroxysmal nocturnal haemoglobinuria.
Natural history of paroxysmal nocturnal haemoglobinuria using modern diagnostic assays.
Eculizumab, a terminal complement inhibitor, improves anaemia in patients with paroxysmal nocturnal haemoglobinuria.
According to the adopted CHMP opinion, "Soliris (eculizumab) is indicated for the treatment of patients with paroxysmal nocturnal haemoglobinuria (PNH).
The 33-year-old carpenter from Bellewstown, Co Meath, suffers from life-threatening blood condition Paroxysmal Nocturnal Haemoglobinuria, which can only be treated using the drug Soliris.
Chapter 11 Paroxysmal nocturnal haemoglobinuria (Peter Hillmen).
For 33-year-old John Duggan, who suffers from rare blood disorder Paroxysmal Nocturnal Haemoglobinuria, his life is priceless.
According to the adopted CHMP opinion, Soliris (eculizumab) is indicated for the treatment of patients with paroxysmal nocturnal haemoglobinuria (PNH).

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