Recent evidence suggests that H pylori can trigger the development of autoimmune atrophic gastritis through a process of molecular mimicry in which the bacterial organisms take on the antigenic appearance of parietal cells
Brodiaea, Dipterostemon, Dichelostemma, and Muilla (formerly Alliaceae, now Themidaceae) are also crassinucellate (Berg, 1978, 1996), whereas all members of Alliaceae lack parietal cells
12], the parietal cells
release this protein and binds with it, hydrochloric acid, and an enzyme called pepsin.
On the other hand, duration of exposure to high plasma concentration of PPIs is longer in PMs and the proton pumps in parietal cells
remain inactivated for longer period resulting in higher pH and a better therapeutic outcome (27-36).
His team stained and microscopically examined parietal cells
from the brains of five trained monkeys and compared them with corresponding cells from four untrained monkeys.
Autoantibodies against parietal cells
and intrinsic factor (IF) were positive.
B6: Required by the parietal cells
in the stomach to produce hydrochloric acid.
Immunologically, the hallmark of pernicious anemia is the presence of autoantibodies to gastric parietal cells
(AGPA), proton pump (H+K+ATPase), and to the cobalamin-absorbing protein, intrinsic factor.
Wilson speculated that marginal ulcers are caused by increased gastric acid production in the setting of surgically induced mucosal disruption and ischemia, and that proton pump inhibitor therapy is partially protective because it squelches acid production by parietal cells
in the gastric pouch.
Autoimmune destruction of the IF-producing gastric parietal cells
leads to IF deficiency and vitamin [B.
Intrinsic factor is secreted by the parietal cells
of the stomach and is required for the intestinal absorption of vitamin [B.
Belmazol, used primarily for hyperacidity problems related to ulcers and gastroesophageal reflux disease, is a proton pump inhibitor which inhibits the hydrogen/potassium ATPase enzyme system at the secretory surface of gastric parietal cells