PA is macrocytic anemia due to vitamin B12 deficiency as a result of deficiency of intrinsic factor because of the atrophy of gastric mucosa and thus the loss of parietal cells
Recent evidence suggests that H pylori can trigger the development of autoimmune atrophic gastritis through a process of molecular mimicry in which the bacterial organisms take on the antigenic appearance of parietal cells
2] receptors at gastric parietal cells
or influence the intracellular mechanisms involved with histamine activity.
The vitamin then forms a complex with intrinsic factor, a specific glycoprotein that is secreted postprandially by parietal cells
in the gastric lining, and moves toward the ileum to attach to receptors on the terminal ileum membrane.
In Potamogeton the parietal cell
divides both anticlinally and periclinally to form four cell layers between the megasporocyte and the nucellar epidermis.
Tests for antibodies to parietal cells
and intrinsic factor also may be ordered.
Development continues with the mitotic division of the archesporium cell, producing a parietal cell
and a primary sporogenous cell (Fig.
Histamine stimulates gastric acid secretion by direct interaction at the parietal cell
12]-binding capacity was normal at 1,122 ng/mL, intrinsic-factor-blocking antibody was negative, and parietal cell
antibodies were normal at < 1:20.
Also among this group, 1 patient had positive intrinsic antibodies, 3 had elevated parietal cell
antibody titers, 7 had high fasting gastrin levels, and 2 of the 12 patients tested had abnormal Schilling tests.
ATPase, the key enzyme in the final acid production pathway within the parietal cell
The stomach's parietal cells
are challenged to determine the parietal cell
health and stomach-emptying time.