parathyroid hormone-related peptide

parathyroid hormone-related peptide (PTHrP),

a hormone that can be produced by tumors, especially of the squamous cell type; massive overproduction can lead to hypercalcemia and other manifestations of hyperparathyroidism. PTHrP exerts a biologic action similar to that of parathyroid hormone (PTH), acting through the same receptor, which is expressed in many tissues but most abundantly in kidney, bone, and growth plate cartilage. It apparently has significant actions during development, but it remains uncertain whether PTHrP circulates at all or has any function in normal human adults. The structure of the gene for human PTHrP is more complex than that of PTH, and varying molecular forms exist, including proteins of 141, 139, and 173 amino acids, which share a significant homology with parathyroid hormone.

par·a·thy·roid hor·mone-re·lated pep·tide

(PTHrP) (par'ă-thī'royd hōr'mōn-rĕ-lā'tĕd pep'tīd)
A hormone that can be produced by tumors, especially of the squamous cell type; massive overproduction can lead to hypercalcemia and other manifestations of hyperparathyroidism. PTHrP exerts a biologic action similar to that of parathyroid hormone (PTH), acting through the same receptor, which is expressed in many tissues but most abundantly in kidney, bone, and growth plate cartilage. It apparently has significant actions during development, but it is uncertain whether PTHrP circulates at all or has any function in normal human adults. The structure of the gene for human PTHrP is more complex than that of PTH, and varying molecular forms exist, including proteins of 141, 139, and 173 amino acids, which share a significant homology with parathyroid hormone.
Compare: bioregulator
References in periodicals archive ?
Traditionally, humoral hypercalcemia of malignancy is referred to the over production of parathyroid hormone-related peptide (PTHrP).
Hypercalcemia in childhood acute lymphoblastic leukemia: frequent implication of parathyroid hormone-related peptide and E2A-HLF from translocation 17;19.
Her parathyroid hormone (PTH) level was normal, but the parathyroid hormone-related peptide (PTHrP) level was higher than the normal values.
Autocrine/paracrine involvement of parathyroid hormone-related peptide in vascular leiomyoma.
Although the CaR plays a key role in the defense against hypercalcaemia, its function can be aberrant in humoral hypercalcaemia of malignancy in which CaR activation stimulates secretion of parathyroid hormone-related peptide (PTHrP) secretion.
Their topics in the fundamental concepts include an overview by the editors, and studies of parathyroid hormone-related peptide and malignancy.
This may reflect a true phenomenon because lead exposure has been reported to accelerate bony maturation by inhibiting the effects of parathyroid hormone-related peptide.
We report a case of squamous cell carcinoma of the oral cavity that presumably elaborated parathyroid hormone-related peptide (PTH-rP) and caused hypercalcemia only after radiotherapy and chemotherapy.
It's called parathyroid hormone-related peptide, or PTHrP.
16,17] The tumor cells stained negatively for chromogranin, synaptophysin, and parathyroid hormone-related peptide.
A topical preparation of parathyroid hormone (1-34), an agonist of parathyroid hormone-related peptide, shuts down epidermal hyperproliferation in psoriasis and may do the same in other disorders, Dr.

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