parathyroid hormone-related peptide

parathyroid hormone-related peptide (PTHrP),

a hormone that can be produced by tumors, especially of the squamous cell type; massive overproduction can lead to hypercalcemia and other manifestations of hyperparathyroidism. PTHrP exerts a biologic action similar to that of parathyroid hormone (PTH), acting through the same receptor, which is expressed in many tissues but most abundantly in kidney, bone, and growth plate cartilage. It apparently has significant actions during development, but it remains uncertain whether PTHrP circulates at all or has any function in normal human adults. The structure of the gene for human PTHrP is more complex than that of PTH, and varying molecular forms exist, including proteins of 141, 139, and 173 amino acids, which share a significant homology with parathyroid hormone.

par·a·thy·roid hor·mone-re·lated pep·tide

(PTHrP) (par'ă-thī'royd hōr'mōn-rĕ-lā'tĕd pep'tīd)
A hormone that can be produced by tumors, especially of the squamous cell type; massive overproduction can lead to hypercalcemia and other manifestations of hyperparathyroidism. PTHrP exerts a biologic action similar to that of parathyroid hormone (PTH), acting through the same receptor, which is expressed in many tissues but most abundantly in kidney, bone, and growth plate cartilage. It apparently has significant actions during development, but it is uncertain whether PTHrP circulates at all or has any function in normal human adults. The structure of the gene for human PTHrP is more complex than that of PTH, and varying molecular forms exist, including proteins of 141, 139, and 173 amino acids, which share a significant homology with parathyroid hormone.
Compare: bioregulator
References in periodicals archive ?
Her parathyroid hormone (PTH) level was normal, but the parathyroid hormone-related peptide (PTHrP) level was higher than the normal values.
Autocrine/paracrine involvement of parathyroid hormone-related peptide in vascular leiomyoma.
The aim of the study is to determine the therapeutic efficacy and safety of PTH (1-34) (a parathyroid hormone-related peptide analog) for the treatment of adult patients with psoriatic lesions.
Their topics in the fundamental concepts include an overview by the editors, and studies of parathyroid hormone-related peptide and malignancy.
This may reflect a true phenomenon because lead exposure has been reported to accelerate bony maturation by inhibiting the effects of parathyroid hormone-related peptide.
We report a case of squamous cell carcinoma of the oral cavity that presumably elaborated parathyroid hormone-related peptide (PTH-rP) and caused hypercalcemia only after radiotherapy and chemotherapy.
It's called parathyroid hormone-related peptide, or PTHrP.
Title: The PK/PD Relationship of a Novel Peptide, KAI-4169, Following Single-Dose Administration to Healthy Young Males Authors: J Shen, A Vick, K Pickthorn, S Huang, G Bell Date/Time: Saturday, June 4, 2011 - 1:30 pm Session Info: Poster Session: Clinical - Parathyroid Hormone & Parathyroid Hormone-Related Peptide I (1:30 PM-3:30 PM)
Parathyroid hormone-related peptide, measured by a midmolecule radioimmunoassay, in various hypercalcaemic and normocalcaemic conditions.
Specifically, he discussed parathyroid hormone, parathyroid hormone-related peptide, and the mechanism of bisphosphonate treatment.

Full browser ?