paraptosis

paraptosis

A programmed cell death pathway that leads to cellular necrosis, by as yet unknown mechanisms.
References in periodicals archive ?
Honokiol induces paraptosis and apoptosis and exhibits schedule-dependent synergy in combination with imatinib in human leukemia cells.
A process similar to apoptosis (programmed cell death), curcumin initiates paraptosis only in breast cancer cells, resulting in their rapid destruction.
Superoxide anion and proteasomal dysfunction contribute to curcumin-induced paraptosis of malignant breast cancer cells.
19, 2000 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, Sperandio, Bredesen, and their colleagues declared this a novel kind of cell suicide, dubbing it paraptosis.
Bredesen notes, however, that these molds and yeasts do follow a process that structurally resembles paraptosis.
Paraptosis may also have become outmoded for higher organisms, he acknowledges.
His team has found that many types of mammalian cells--perhaps most--can end their days via paraptosis.
Conversely, he points out, because malignant cells ignore signals to undergo apoptosis, cancer researchers might enlist paraptosis for new therapies.
This process clearly differs from paraptosis, which is characterized by swelling but also creates vacuoles.