paraprotein


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paraprotein

 [par″ah-pro´tēn]
a normal or abnormal plasma protein appearing in large quantities as a result of some pathologic condition, now replaced in most contexts by the term m component.

par·a·pro·tein

(par'ă-prō'tēn),
1. A monoclonal immunoglobulin of blood plasma, observed electrophoretically as an intense band in γ, β, or α regions, due to an isolated increase in a single immunoglobulin type as a result of a clone of plasma cells arising from the abnormal rapid multiplication of a single cell. The finding of a paraprotein in a patient's serum indicates the presence of a proliferating clone of immunoglobulin-producing cells and may be seen in a variety of malignant, benign, or nonneoplastic diseases.
[para + protein, fr. G. protos, first]

paraprotein

/para·pro·tein/ (-pro´tēn) a normal or abnormal plasma protein appearing in large quantities as a result of a pathological condition; term now largely replaced by M component.

paraprotein

[-prō′tēn]
any of the incomplete monoclonal immunoglobulins that occur in plasma cell disorders.

M spike

A term of art referring to a zone of increased concentration of a monoclonal immunoglobulin when seen by serum electrophoresis.

par·a·pro·tein

(par'ă-prō'tēn)
1. A monoclonal immunoglobulin of the blood plasma, produced by a clone of plasma cells arising from the abnormal rapid multiplication of a single cell. Paraprotein in serum may be seen in various malignant, benign, or nonneoplastic diseases.
2. Synonym(s): monoclonal immunoglobulin.
[para + protein, fr. G. protos, first]

paraprotein

An abnormal plasma protein such as the MONOCLONAL immunoglobulin in MYELOMATOSIS.

Paraprotein

M-protein; abnormal immunoglobulin produced in multiple myeloma.
Mentioned in: Multiple Myeloma

paraprotein

immunoglobulin produced by a clone of neoplastic plasma cells proliferating abnormally, e.g. myeloma proteins and cryoglobulins. See also monoclonal gammopathy.
References in periodicals archive ?
A decreased anion gap (1-3 mEq/L) is consistent with elevated protein as seen in some malignancies, especially with a monoclonal paraprotein (multiple myeloma).
Findings of normal bone marrow, an absence of lytic bone lesions on skeletal studies, and low paraprotein levels are necessary to establish the diagnosis of extramedullary plasmacytoma.
Almost all patients with malignant paraprotein disorders have clinically significant bleeding, and thrombocytopenia with poorly functional platelets is the most likely cause.
The systemic capillary leak syndrome (SCLS) is characterized by spontaneous recurrent episodes of hypotension, haemoconcentration, generalized oedema, and in most cases, the presence of a paraprotein.
Less frequently, kappa light chains or even a paraprotein of the IgM or IgA class may be found.
Paraprotein interference with colorimetry of phosphate in serum of some patients with multiple myeloma.
7,8) The paraprotein may also have autoantibody or cryoglobulin activity resulting in autoimmune phenomena or cryoglobulinemia.
Blood test results were normal apart from a 4g/L IgG kappa paraprotein in the serum with no immunoparesis.
Most patients with multiple myeloma, however, have cells that produce a form of immunoglobulin called paraprotein (or M protein), which does not benefit the body.
1B) revealed a large IgA k paraprotein in the [beta]1-[beta]2 interzone (Fig.
This is called a paraprotein and it is present in the blood and/or urine in about 99% of cases.