paraprotein


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paraprotein

 [par″ah-pro´tēn]
a normal or abnormal plasma protein appearing in large quantities as a result of some pathologic condition, now replaced in most contexts by the term m component.

par·a·pro·tein

(par'ă-prō'tēn),
1. A monoclonal immunoglobulin of blood plasma, observed electrophoretically as an intense band in γ, β, or α regions, due to an isolated increase in a single immunoglobulin type as a result of a clone of plasma cells arising from the abnormal rapid multiplication of a single cell. The finding of a paraprotein in a patient's serum indicates the presence of a proliferating clone of immunoglobulin-producing cells and may be seen in a variety of malignant, benign, or nonneoplastic diseases.
[para + protein, fr. G. protos, first]

paraprotein

/para·pro·tein/ (-pro´tēn) a normal or abnormal plasma protein appearing in large quantities as a result of a pathological condition; term now largely replaced by M component.

paraprotein

[-prō′tēn]
any of the incomplete monoclonal immunoglobulins that occur in plasma cell disorders.

M spike

A term of art referring to a zone of increased concentration of a monoclonal immunoglobulin when seen by serum electrophoresis.

par·a·pro·tein

(par'ă-prō'tēn)
1. A monoclonal immunoglobulin of the blood plasma, produced by a clone of plasma cells arising from the abnormal rapid multiplication of a single cell. Paraprotein in serum may be seen in various malignant, benign, or nonneoplastic diseases.
2. Synonym(s): monoclonal immunoglobulin.
[para + protein, fr. G. protos, first]

paraprotein

An abnormal plasma protein such as the MONOCLONAL immunoglobulin in MYELOMATOSIS.

Paraprotein

M-protein; abnormal immunoglobulin produced in multiple myeloma.
Mentioned in: Multiple Myeloma

paraprotein

immunoglobulin produced by a clone of neoplastic plasma cells proliferating abnormally, e.g. myeloma proteins and cryoglobulins. See also monoclonal gammopathy.
References in periodicals archive ?
Laboratory studies show an abnormal paraprotein in 90% of cases.
16] only seven out of 10 HIV-positive MM patients showed paraproteins of the IgG type and three patients were found to have an IgA paraprotein, K-light chain disease or non-secretory myeloma.
Patients with MF-MM had advanced myeloma bone disease (MBD), significantly lower clonal plasma cell infiltration in bone marrow, and lower paraprotein level.
Under these circumstances, a free double-membrane vesicle, derived from a mitochondrion or the rough endoplasmic reticulum, encapsulates cytoplasmic materials such as paraprotein, cellular metabolites, or injured organelles, to form autophagosomes.
The NZIMLS best presenter was awarded to Claudia Sugrue, for her presentation on an IgE paraprotein and the runner up best presenter was awarded to Maria Carter for her presentation on Beer Potomania.
In patients with immune complex type MPGN, the paraprotein likely forms part of the immune complex causing activation of the classic complement pathway and resulting in renal injury with both abnormal immunoglobulin and complement on immunohistochemistry.
MGUS is a condition resembling multiple myeloma in which a paraprotein is found in the blood.
His serum immunoglobulins were normal and no serum paraprotein was detected.
Serum protein electrophoresis did not reveal the presence of a paraprotein.
Key facts about disease MYELOMA is a blood cancer where malignant plasma cells in the bone marrow produce paraprotein - an abnormal antibody which can't fight infection.
The factors that predispose to Auer rod-like inclusions in myeloma are unknown; however, in all reported cases paraprotein was of the kappa type.