paraneoplastic syndromes

paraneoplastic syndromes

[-nē′əplas′tik]

Etymology: Gk, para + neos, new, plassein, to mold, syn, together, dromos, course

the indirect effects of a tumor that occur distant to the tumor or metastatic site. They may result from the production of active proteins, polypeptides, or inactive hormones by the tumor.

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paraneoplastic syndrome

Oncology A co-morbid condition due to the indirect–remote or 'biologic' effects of malignancy, which may be the first sign of a neoplasm or its recurrence; PSs occur in > 15% of CAs, are caused by hormones, growth factors, biological response modifiers, and other as-yet unidentified factors, and may regress with treatment of the primary tumor. See Ectopic hormone.

Paraneoplastic syndromes

GI tract, eg anorexia, vomiting, protein-losing enteropathy, liver disease

Hematologic, eg leukemoid reaction, reactive eosinophilia, peripheral 'cytoses or 'cytopenias, hemolysis, DIC, thromboembolism, thrombophlebitis migrans

Hormonal effects

Metabolic disease, eg lactic acidosis, hypertrophic pulmonary osteoarthropathy, hyperamylasemia, hyperlipidemia

Neuromuscular, eg peripheral neuropathy, myopathy, CNS, spinal cord degeneration, inflammation

Renal, eg nephrotic syndrome, uric acid nephropathy

Skin, eg bullous mucocutaneous lesions, acquired ichthyosis, acanthosis nigricans, dermatomyositis

Others, eg callus formation, hypertension, and amyloidosis