paraneoplastic syndrome


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paraneoplastic syndrome

 [par″ah-ne″o-plas´tik]
a collective term for disorders arising from metabolic effects of cancer on tissues remote from the tumor; such disorders may, for example, appear as primary endocrine, hematologic, or neuromuscular disorders.

par·a·ne·o·plas·tic syn·drome

a syndrome directly resulting from a malignant neoplasm, but not resulting from the presence of tumor cells in the affected parts.

paraneoplastic syndrome

Oncology A co-morbid condition due to the indirect–remote or 'biologic' effects of malignancy, which may be the first sign of a neoplasm or its recurrence; PSs occur in > 15% of CAs, are caused by hormones, growth factors, biological response modifiers, and other as-yet unidentified factors, and may regress with treatment of the primary tumor. See Ectopic hormone.
Paraneoplastic syndromes
GI tract, eg anorexia, vomiting, protein-losing enteropathy, liver disease
Hematologic, eg leukemoid reaction, reactive eosinophilia, peripheral 'cytoses or 'cytopenias, hemolysis, DIC, thromboembolism, thrombophlebitis migrans
Hormonal effects
Metabolic disease, eg lactic acidosis, hypertrophic pulmonary osteoarthropathy, hyperamylasemia, hyperlipidemia
Neuromuscular, eg peripheral neuropathy, myopathy, CNS, spinal cord degeneration, inflammation
Renal, eg nephrotic syndrome, uric acid nephropathy
Skin, eg bullous mucocutaneous lesions, acquired ichthyosis, acanthosis nigricans, dermatomyositis
Others, eg callus formation, hypertension, and amyloidosis

par·a·ne·o·plas·tic syn·drome

(par'ă-nē-ō-plas'tik sin'drōm)
A syndrome directly resulting from a malignant neoplasm, but not resulting from the presence of tumor cells in the affected parts.

Paraneoplastic syndrome

A set of symptoms that is associated with cancer but is not directly caused by the cancer.
Mentioned in: Thymoma

par·a·ne·o·plas·tic syn·drome

(par'ă-nē-ō-plas'tik sin'drōm)
Syndrome directly resulting from a malignant neoplasm, but not resulting from presence of tumor cells.

paraneoplastic

auxiliary to neoplasia.

paraneoplastic syndrome
a collective term for disorders arising from metabolic effects of cancer on tissues remote from the tumor; such disorders may, for example, appear as primary endocrine, hematological or neuromuscular disorders. See also pseudohyperparathyroidism.
References in periodicals archive ?
Non-small-cell lung cancer associated with excessive eosinophilia and secretion of interleukin-5 as a paraneoplastic syndrome.
There is an ongoing debate about the co-occurrence of AOSD and solid cancers; it is controversial whether it is a paraneoplastic syndrome or just a coincidence.
In all cancer patients, it should not be forgotten that hypercalcemia is a serious and frequently seen paraneoplastic syndrome, and every patient should be monitored closely in consideration of this entity.
A surgical operation may determine the route of depressive disorders, when they are caused by endocrine tumours or paraneoplastic syndromes.
The incidental finding of hypercalcaemia may not have been due to a paraneoplastic syndrome as the patient underwent excision of a parathyroid adenoma later in 2011.
A chest computed tomography (CT) scan revealed a paratracheal mass, raising clinical suspicion for paraneoplastic syndrome due to lung cancer, and an abdominal CT scan revealed only diverticulosis and abdominopelvic ascites.
11) reported DM as a paraneoplastic syndrome that developed in a patient with uterine carcinosarcoma.
Malignancy can be associated with a number of musculoskeletal manifestations that may be caused by direct tumor invasion into bones and joints, as a paraneoplastic syndrome, and through altered immune surveillance (Table 1).
We describe a case with triple paraneoplastic syndrome including hypercalcemia, leukocytosis and thrombocytosis as multiple hematological paraneoplastic syndromes in a patient with renal pelvis SCC.
Bleeding in patients with cancer can be caused by a variety of factors, including platelet quantity and quality, changes in clotting factors, paraneoplastic syndrome, or even type of chemotherapy treatment.
For use as an alternative to conventional imaging during staging to determine the true extent of disease at the initial diagnosis of patients with small cell lung cancer; in restaging following initial treatment to evaluate response, and in diagnosing occult small cell lung cancer in patients with paraneoplastic syndrome.

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