Ischemic stroke in a patient with Crohn's disease: a confirmed paradoxical embolism
mechanism, Arq Neur-Psiquiatr.
5, the occurrence of paradoxical embolism
and documented platypnea-orthodeoxia.
Key Words: patent foramen ovale, atrial septal defect, percutaneous closure, cerebrovascular accident, paradoxical embolism
A paradoxical embolism
occurs when a blood clot travels from the right side of the heart to the left side of the heart, often through a PFO, and can then travel directly to the brain, causing an ischemic stroke.
Because approximately 60% of these events can be attributed to conventional causes, the annual risk attributed to paradoxical embolism
has been estimated at 28 per 100.
No evidence of intracardiac shunting was seen on echo and a lower extremity doppler ultrasound showed no evidence of deep vein thrombosis to suggest paradoxical embolism
is an unusual cause of cerebrovascular incidents in the elderly.
It is always possible that DVT may lead to systemic embolism through the PFO, called as paradoxical embolism
is another possibility in this setting.
CLOSURE I is NMT's pivotal clinical trial designed to evaluate the effectiveness of the STARFlex(R) technology in preventing recurrent stroke and/or TIA due to a presumed, paradoxical embolism
through a PFO.
The devices are indicated for patients with recurrent cryptogenic stroke caused by a presumed paradoxical embolism
through a PFO who have failed conventional drug therapy.
The procedure permanently closes the patent foramen ovale and lowers, if not eliminates, the possibility of paradoxical embolism
originating somewhere else in the body and subsequently crossing the atrial septum to the left heart.